dc.contributor.author | Kanter, Mehmet | |
dc.contributor.author | GEDİKBAŞI, Asuman | |
dc.contributor.author | Topcu, Birol | |
dc.contributor.author | Erboga, Mustafa | |
dc.contributor.author | Karakaya, Osman | |
dc.contributor.author | Alpsoy, Seref | |
dc.contributor.author | Aktas, Cevat | |
dc.contributor.author | Uygur, Ramazan | |
dc.date.accessioned | 2021-03-03T16:54:48Z | |
dc.date.available | 2021-03-03T16:54:48Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Alpsoy S., Aktas C., Uygur R., Topcu B., Kanter M., Erboga M., Karakaya O., GEDİKBAŞI A., "Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats", JOURNAL OF APPLIED TOXICOLOGY, cilt.33, sa.3, ss.202-208, 2013 | |
dc.identifier.issn | 0260-437X | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_46e80ddb-98bc-473d-afe8-ad40adb8a5ab | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/51232 | |
dc.identifier.uri | https://doi.org/10.1002/jat.1738 | |
dc.description.abstract | The aim of this study was to investigate the antioxidant and anti-apoptotic effects of onion (Allium cepa) extracts (ACE) on doxorubicin (DOX)-induced cardiotoxicity. The rats in the ACE-pretreated group were given a daily dose of 1 ml ACE for 14 days. To induce cardiotoxicity, DOX (30 mg kg-1 body weight) was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h. To date, no such studies have been performed on the cardioprotective and anti-apoptotic potential of ACE on DOX-induced cardiotoxicity. Our data indicate a significant reduction in the activity of in situ identification of apoptosis using terminal dUTP nick end-labeling in cardiomyocytes of the DOX-treated group with ACE therapy. The DOX-treated with ACE groups showed a significant decrease in malondialdehyde levels, and increased activities of superoxide dismutase, glutathione and glutathione peroxidase in comparison with the DOX-treated group. Creatine kinase, creatine kinase MB, lactate dehydrogenase activities and cardiac troponin I levels were significantly decreased in the DOX + ACE group in comparison with the DOX group. These biochemical and histological disturbances were effectively attenuated on pretreatment with ACE. The present study showed that ACE may be a suitable cardioprotector against toxic effects of DOX. Copyright (C) 2011 John Wiley & Sons, Ltd. | |
dc.language.iso | eng | |
dc.subject | Temel Bilimler | |
dc.subject | Farmasötik Toksikoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Meslek Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | TOKSİKOLOJİ | |
dc.title | Antioxidant and anti-apoptotic effects of onion (Allium cepa) extract on doxorubicin-induced cardiotoxicity in rats | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF APPLIED TOXICOLOGY | |
dc.contributor.department | Tekirdağ Namık Kemal Üniversitesi , , | |
dc.identifier.volume | 33 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 202 | |
dc.identifier.endpage | 208 | |
dc.contributor.firstauthorID | 2215041 | |