dc.contributor.author | Yilmazer, Selma | |
dc.contributor.author | Dursun, Erdinc | |
dc.contributor.author | Gezen-Ak, Duygu | |
dc.date.accessioned | 2021-03-03T16:45:31Z | |
dc.date.available | 2021-03-03T16:45:31Z | |
dc.identifier.citation | Dursun E., Gezen-Ak D., Yilmazer S., "Beta Amyloid Suppresses the Expression of the Vitamin D Receptor Gene and Induces the Expression of the Vitamin D Catabolic Enzyme Gene in Hippocampal Neurons", DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, cilt.36, ss.76-86, 2013 | |
dc.identifier.issn | 1420-8008 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_4603c57b-3d21-401c-9a13-bab781d65658 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/50699 | |
dc.identifier.uri | https://doi.org/10.1159/000350319 | |
dc.description.abstract | Background/Aims: The beta amyloid aggregations present in Alzheimer's disease affect neurons through various toxic alterations. The aim of this study was to determine the expression of the vitamin D receptor (VDR), 25-hydroxyvitamin D-3 24-hydroxylase (an accelerator of vitamin D catabolism), and the L-type voltage-sensitive calcium channel A1C (LVSCC-A1C) in hippocampal neurons in response to beta amyloid and vitamin D treatments to test the protective effects of vitamin D and the probable effects of beta amyloid on vitamin D catabolism. Methods: The expression of the VDR, 24-hydroxylase (24OHase) and LVSCC-A1C mRNAs were studied using quantitative real-time polymerase chain reaction, and the cytotoxicity levels were determined by an ELISA in primary hippocampal neuron cultures prepared from Sprague-Dawley rat embryos. Results: Our results demonstrated that beta amyloid suppressed the expression of VDR mRNA and induced the expression of 24OHase and LVSCC-A1C mRNAs. Conclusion: Beta amyloid may disrupt the vitamin D-VDR pathway and cause defective utilization of vitamin D by suppressing the level of the VDR and elevating the level of 24OHase. Copyright (C) 2013 S. Karger AG, Basel | |
dc.language.iso | eng | |
dc.subject | Psikiyatri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Geriatri | |
dc.subject | Nöroloji | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | KLİNİK NEUROLOJİ | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp | |
dc.subject | GERİATRİK VE GERONTOLOJİ | |
dc.title | Beta Amyloid Suppresses the Expression of the Vitamin D Receptor Gene and Induces the Expression of the Vitamin D Catabolic Enzyme Gene in Hippocampal Neurons | |
dc.type | Makale | |
dc.relation.journal | DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | |
dc.contributor.department | İstanbul Üniversitesi , Cerrahpaşa Tıp Fakültesi , Temel Tıp Bilimleri Bölümü | |
dc.identifier.volume | 36 | |
dc.identifier.startpage | 76 | |
dc.identifier.endpage | 86 | |
dc.contributor.firstauthorID | 6332 | |