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dc.contributor.authorERKURT, MEHMET ALİ
dc.contributor.authorSOYER, NUR
dc.contributor.authorGunduz, Mehmet
dc.contributor.authorTekgunduz, Emre
dc.contributor.authorDeveci, Burak
dc.contributor.authorOzdogu, Hakan
dc.contributor.authorERMİŞ TURAK, Esra
dc.contributor.authorGÖKER, HAKAN
dc.contributor.authorVURAL, FİLİZ
dc.contributor.authorBesisik, Sevgi
dc.contributor.authorŞAHİN, HANDAN HAYDAROĞLU
dc.contributor.authorOkay, Mufide
dc.contributor.authorKUKU, İRFAN
dc.contributor.authorHindilerden, Ipek Yonal
dc.contributor.authorTOPÇUOĞLU, PERVİN
dc.contributor.authorAltuntas, Fevzi
dc.contributor.authorKaradogan, Ihsan
dc.contributor.authorPEHLİVAN, MUSTAFA
dc.contributor.authorÜNAL, ALİ
dc.date.accessioned2021-03-03T16:39:47Z
dc.date.available2021-03-03T16:39:47Z
dc.date.issued2020
dc.identifier.citationSOYER N., Gunduz M., Tekgunduz E., Deveci B., Ozdogu H., ŞAHİN H. H. , ERMİŞ TURAK E., Okay M., KUKU İ., Hindilerden I. Y. , et al., "Incidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of Turkish hematology research and education group (ThREG).", Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis, cilt.59, sa.4, ss.102827, 2020
dc.identifier.issn1473-0502
dc.identifier.othervv_1032021
dc.identifier.otherav_456e9c90-4f95-4a96-aaf5-2b9bbe403171
dc.identifier.urihttp://hdl.handle.net/20.500.12627/50346
dc.identifier.urihttps://doi.org/10.1016/j.transci.2020.102827
dc.description.abstractHepatic sinusoidal obstruction syndrome (HSOS) is a potentially life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively evaluated the incidence, risk factors, treatment and survival for HSOS after allo-HSCT in Turkey. We also reported our experience of defibrotide (DF) for HSOS prophylaxis in high-risk (HR) patients. Across Turkey, 1153 patients from 10 centers were enrolled in the study. We evaluated the medical records of patients who were treated with allo-SCT between January 2012 and December 2015. The study included 1153 patients (687 males/466 females) with median age of 38 (15 - 71) years. The incidence of HSOS was 7.5 % (n = 86). The incidences of HSOS in the HR/DF +, HR/DF- and standard risk (SR) group were 8%, 66.7 % and 6.2 %, respectively. The rate of HSOS development was not statistically different between HR/DF + and SR group (p = 0.237). HSOS prophylaxis (defibrotide) was significantly decreased HSOS-related mortality (p = 0.004). The incidence of HSOS was found similar to literature in this large Turkish cohort. Defibrotide prophylaxis appears to be associated with low incidence of HSOS development and reduced HSOS-related mortality. Although these results are promising, future studies are needed to support the efficacy of defibrotide prophylaxis in patients with risk of HSOS.
dc.language.isoeng
dc.subjectTıp
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectHematoloji
dc.subjectHEMATOLOJİ
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.titleIncidence and risk factors for hepatic sinusoidal obstruction syndrome after allogeneic hematopoietic stem cell transplantation: A retrospective multicenter study of Turkish hematology research and education group (ThREG).
dc.typeMakale
dc.relation.journalTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
dc.contributor.departmentEge Üniversitesi , Rektörlük , Bağlı Bölümler
dc.identifier.volume59
dc.identifier.issue4
dc.identifier.startpage102827
dc.identifier.endpage102827
dc.contributor.firstauthorID2285600


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