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F-18-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management

dc.contributor.authorSayman, Haluk B.
dc.contributor.authorTing, Richard
dc.contributor.authorEhdaie, Behfar
dc.contributor.authorAkin, Oguz
dc.contributor.authorAras, Omer
dc.contributor.authorKommidi, Harikrishna
dc.contributor.authorGuo, Hua
dc.contributor.authorNurili, Fuad
dc.contributor.authorVedvyas, Yogindra
dc.contributor.authorJin, Moonsoo M.
dc.contributor.authorMcClure, Timothy D.
dc.date.accessioned2021-03-03T16:17:07Z
dc.date.available2021-03-03T16:17:07Z
dc.date.issued2018
dc.identifier.citationKommidi H., Guo H., Nurili F., Vedvyas Y., Jin M. M. , McClure T. D. , Ehdaie B., Sayman H. B. , Akin O., Aras O., et al., "F-18-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management", JOURNAL OF MEDICINAL CHEMISTRY, cilt.61, sa.9, ss.4256-4262, 2018
dc.identifier.issn0022-2623
dc.identifier.othervv_1032021
dc.identifier.otherav_43607be3-2ee6-4300-92a4-10025c49b965
dc.identifier.urihttp://hdl.handle.net/20.500.12627/49012
dc.identifier.urihttps://doi.org/10.1021/acs.jmedchem.8b00240
dc.description.abstract[E-18/19]-4, an anionic GCPII/PSMA inhibitor for image-guided intervention in prostate cancer, is described. [19F]4 is radiolabeled with a radiochemical yield that is >27% and a molar activity of 190 +/- 50 mCi/ptmol in a <1 h, one-step, aqueous isotopic exchange reaction. [F-19]-4 allows PSMA expression to be imaged by fluorescence (FL) and [18F]-PET. PC3-PIP (PSMA-positive, EC50 = 6.74 +/- 1.33 nM) cancers are specifically delineated in mice that bear 3 million (18 mg) PC3-PIP and PC3 (control, PSMA-negative) cells. Colocalization of [F-18/19]-4 PET, fluorescence, scintillated biodistribution, and PSMA expression are observed.
dc.language.isoeng
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleF-18-Positron Emitting/Trimethine Cyanine-Fluorescent Contrast for Image-Guided Prostate Cancer Management
dc.typeMakale
dc.relation.journalJOURNAL OF MEDICINAL CHEMISTRY
dc.contributor.departmentCornell University , ,
dc.identifier.volume61
dc.identifier.issue9
dc.identifier.startpage4256
dc.identifier.endpage4262
dc.contributor.firstauthorID253055


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