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dc.contributor.authorKoc, Fatma Ebru
dc.contributor.authorAltincekic, Tuba Gurkaynak
dc.date.accessioned2021-03-02T18:14:44Z
dc.date.available2021-03-02T18:14:44Z
dc.identifier.citationKoc F. E. , Altincekic T. G. , "Investigation of gelatin/chitosan as potential biodegradable polymer films on swelling behavior and methylene blue release kinetics", POLYMER BULLETIN, 2020
dc.identifier.issn0170-0839
dc.identifier.othervv_1032021
dc.identifier.otherav_33ef031e-fdf4-4bad-9fa8-44477f7d705b
dc.identifier.urihttp://hdl.handle.net/20.500.12627/4760
dc.identifier.urihttps://doi.org/10.1007/s00289-020-03280-7
dc.description.abstractThe aim of this study was to design genipin-cross-linked gelatin/chitosan films and investigate the swelling behavior of these films and also investigate the release kinetics for methylene blue as a model drug. It was shown that the change in the gelatin ratio did not have much effect on the swelling behavior, but the change in genipin concentration had a significant effect on the swelling behavior of the films. The influence of pH was investigated on the release profiles of Methylene Blue. When the diffusion exponent value of "n" was calculated, it was observed that the diffusion type in an acidic environment (pH 1.5) changed from anomalous to less Fickian due to the increase in genipin ratio. In basic conditions (pH 8.0), completely anomalous diffusion behavior was observed. As a result of the ninhydrin test, it was revealed that the cross-linking ratio reached up to 65% when 1.5% genipin was used. In the methylene blue model drug release studies, a very controllable release was observed, complying with the zero-order kinetic model at low pH (pH 1.5), except for the 1.5% genipin ratio. At high pH (pH 8.0), only 4.1 percent of the model drug was released. It was also observed that a zero-order kinetic model was seen for all genipin ratios. "K-0," the kinetic rate constant of model drug release, was calculated an average 0.025 mg.min(-1)at pH 1.5 and 0.001 mg.min(-1)at pH 8.0, respectively. These values show that release rate at pH 8.0 was significantly lower than at pH 1.5.
dc.language.isoeng
dc.subjectTemel Bilimler
dc.subjectPolimer Karakterizasyonu
dc.subjectFizikokimya
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectPOLİMER BİLİMİ
dc.titleInvestigation of gelatin/chitosan as potential biodegradable polymer films on swelling behavior and methylene blue release kinetics
dc.typeMakale
dc.relation.journalPOLYMER BULLETIN
dc.contributor.departmentİstanbul Üniversitesi-Cerrahpaşa , ,
dc.contributor.firstauthorID2282109


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