dc.contributor.author | ATMACA, MUKADDER | |
dc.contributor.author | BİLGİN, HAKKI MURAT | |
dc.contributor.author | DENİZ OBAY, BASRA | |
dc.contributor.author | Kelle, Mustafa | |
dc.contributor.author | Oflazoglu, Hueda Diken | |
dc.contributor.author | Demirtas, Berjan | |
dc.contributor.author | Tasdemir, Ezel | |
dc.contributor.author | YILDIRIM, YAŞAR | |
dc.date.accessioned | 2021-03-03T15:23:15Z | |
dc.date.available | 2021-03-03T15:23:15Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Tasdemir E., ATMACA M., YILDIRIM Y., BİLGİN H. M. , Demirtas B., DENİZ OBAY B., Kelle M., Oflazoglu H. D. , "Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats", HUMAN & EXPERIMENTAL TOXICOLOGY, cilt.36, sa.3, ss.295-301, 2017 | |
dc.identifier.issn | 0960-3271 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_3eacf9bc-7840-4626-a6cc-98cd3801838a | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/45997 | |
dc.identifier.uri | https://doi.org/10.1177/0960327116649675 | |
dc.description.abstract | In the present study, coumarin and some coumarin derivatives (esculetin, scoparone, and 4-methylumbelliferone) were investigated for their lipid-lowering effect in rats. Male Sprague-Dawley rats (150-200 g) were divided into six groups and each group comprised of five rats. Hepatic injury-dependent hyperlipidemia was induced by carbon tetrachloride (CCl4, 1.25 ml/kg). Coumarin and coumarin derivatives esculetin (35 mg/kg), scoparone (35 mg/kg), 4-methylumbelliferone (35 mg/kg), or coumarin (30 mg/kg) were administered to experimental groups at 12-h intervals. Animals received the derivatives esculetin, scoparone or 4-methylumbelliferone prior to the administration of a single toxic dose of CCl4. Serum total cholesterol (TC), triglyceride (TG), very low-density lipoprotein cholesterol (VLDL-C), and low-density lipoprotein cholesterol (LDL-C) levels significantly increased in CCl4-treated group (p < 0.05, p < 0.01, p < 0.01, and p < 0.05, respectively), while levels of serum high-density lipoprotein cholesterol (HDL-C) decreased (p < 0.01). 4-Methylumbelliferone had no recovery effects on serum TC levels, however, significantly prevented CCl4-induced hyperlipidemia by reducing TG and VLDL-C levels (p < 0.05 and p < 0.05, respectively). In addition, coumarin had no recovery effect on any of the serum lipid parameters against CCl4-induced hyperlipidemia. Among the coumarin derivatives only esculetin and scoparone significantly prevented serum HDL-C in CCl4-induced dyslipidemia. The results from this study indicate that the chemical structure of coumarins plays an important role on the regulation of serum lipid profiles. | |
dc.language.iso | eng | |
dc.subject | Farmasötik Toksikoloji | |
dc.subject | TOKSİKOLOJİ | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Meslek Bilimleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Influence of coumarin and some coumarin derivatives on serum lipid profiles in carbontetrachloride-exposed rats | |
dc.type | Makale | |
dc.relation.journal | HUMAN & EXPERIMENTAL TOXICOLOGY | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 36 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 295 | |
dc.identifier.endpage | 301 | |
dc.contributor.firstauthorID | 241058 | |