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dc.contributor.authorUslu, E
dc.contributor.authorUzun, Hafize
dc.contributor.authorBELCE, Ahmet
dc.contributor.authorAydin, Seval
dc.contributor.authorOzaras, Reşat
dc.contributor.authorDÜMEN, Emek
dc.contributor.authorALTUĞ, Tuncay
dc.contributor.authorŞENTÜRK, H
dc.contributor.authorTAHAN, V
dc.date.accessioned2021-03-03T15:15:11Z
dc.date.available2021-03-03T15:15:11Z
dc.date.issued2002
dc.identifier.citationAydin S., Ozaras R., Uzun H., BELCE A., Uslu E., TAHAN V., ALTUĞ T., DÜMEN E., ŞENTÜRK H., "N-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue", TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, cilt.198, sa.2, ss.71-77, 2002
dc.identifier.issn0040-8727
dc.identifier.otherav_3e0d2c94-92be-4fe8-a4eb-76bfd2f12b7e
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/45580
dc.identifier.urihttps://doi.org/10.1620/tjem.198.71
dc.description.abstractChronic ethanol administration is able to induce an oxidative stress in the central nervous system. N-Acetylcysteine (NAC) has antioxidant properties; as a sulphydryl donor, it contributes to the regeneration of glutathione and it acts through a direct reaction with hydroxyl radicals. In this study we investigated a possible beneficial effect of NAC on some of the free radical related parameters. Twenty four male Wistar rats were divided in to three groups and were given ethanol (Group 1), ethanol and NAC (Group 2) and isocaloric dextrose (Group 3). Ethanol and NAC were given intragastrically at doses of 6 g/kg/day and 1 g/kg/day, respectively. Our results show that chronic ethanol intake elicits statistically significant increase in MDA and NO levels and decrease in SOD and GSH levels in both plasma and brain (p < 0.001). GPx levels decreased in erythrocytes (p < 0.001). CAT activity showed significant decrease only in brain samples (p < 0.001). NAC administration effectively restores the above results to nearly normal levels. Therefore we suggest that reactive free radicals are, at least partly, involved in the ethanol-induced injury of brain cells and NAC mitigate the toxic effects of ethanol on the oxidant-antioxidant system of rat plasma and brain. (C) 2002 Tohoku University Medical Press. (C) 2002 Tohoku University Medical Press.
dc.language.isoeng
dc.subjectDahili Tıp Bilimleri
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTIP, ARAŞTIRMA VE DENEYSEL
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectTıbbi Ekoloji ve Hidroklimatoloji
dc.subjectTemel Tıp Bilimleri
dc.titleN-acetylcysteine reduced the effect of ethanol on antioxidant system in rat plasma and brain tissue
dc.typeMakale
dc.relation.journalTOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
dc.contributor.department, ,
dc.identifier.volume198
dc.identifier.issue2
dc.identifier.startpage71
dc.identifier.endpage77
dc.contributor.firstauthorID18510


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