dc.contributor.author | Zhao, Q | |
dc.contributor.author | Smith, ML | |
dc.contributor.author | Siesjo, BK | |
dc.contributor.author | Albayrak, S | |
dc.date.accessioned | 2021-03-03T15:09:59Z | |
dc.date.available | 2021-03-03T15:09:59Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | Albayrak S., Zhao Q., Siesjo B., Smith M., "Effect of transient focal ischemia on blood-brain barrier permeability in the rat: Correlation to cell injury", ACTA NEUROPATHOLOGICA, cilt.94, sa.2, ss.158-163, 1997 | |
dc.identifier.issn | 0001-6322 | |
dc.identifier.other | av_3d8ba123-c9bc-4023-81b7-5e60a4f54ad2 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/45257 | |
dc.identifier.uri | https://doi.org/10.1007/s004010050688 | |
dc.description.abstract | Prolonged ischemia is known to damage the blood-brain barrier, causing an increase in vascular permeability to proteins. We studied the time course of extravasation of endogenous albumin in rats after I and 2 h of middle cerebral artery (MCA) occlusion followed by 6, 12, and 24 h of recirculation. In a separate group of rats that had undergone 1 h of MCA occlusion and 6 h of recirculation, influx of [C-14]aminoisobutyric acid (AIB) from blood to brain was also measured. After I h of occlusion followed by 6 h of recirculation, neuronal damage was evident in caudoputamen, but there were no signs of blood-brain barrier leakage to either AIB or albumin, At 12 h. the caudoputamen contained extravasated albumin, and a; 24 h extravasation was extended to the somatosensory cortex. Animals subjected to 2 h of MCA occlusion showed albumin extravasation in caudoputamen already al. 6 h of recirculation, and at 12 and 24 It albumin was abundant in the major part of the right hemisphere, This study suggests that damage to neurons precedes leakage of the blood-brain barrier. Even a relatively short period of ischemia such as 1 h will result in markedly increased vascular permeability. However, a longer transient ischemic insult disrupts the blood-brain barrier earlier than a shorter one. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Nöroloji | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | PATOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sinirbilim ve Davranış | |
dc.subject | NEUROSCIENCES | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | KLİNİK NEUROLOJİ | |
dc.title | Effect of transient focal ischemia on blood-brain barrier permeability in the rat: Correlation to cell injury | |
dc.type | Makale | |
dc.relation.journal | ACTA NEUROPATHOLOGICA | |
dc.contributor.department | , , | |
dc.identifier.volume | 94 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 158 | |
dc.identifier.endpage | 163 | |
dc.contributor.firstauthorID | 119259 | |