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dc.contributor.authorAmare, Azmeraw T.
dc.contributor.authorTiemeier, Henning
dc.contributor.authorBultmann, Ute
dc.contributor.authorSnieder, Harold
dc.contributor.authorHartman, Catharina A.
dc.contributor.authorDirek, Neşe
dc.contributor.authorVaez, Ahmad
dc.contributor.authorHsu, Yi-Hsiang
dc.contributor.authorKamali, Zoha
dc.contributor.authorHoward, David M.
dc.contributor.authorMcIntosh, Andrew M.
dc.date.accessioned2021-03-02T17:43:03Z
dc.date.available2021-03-02T17:43:03Z
dc.date.issued2020
dc.identifier.citationAmare A. T. , Vaez A., Hsu Y., Direk N., Kamali Z., Howard D. M. , McIntosh A. M. , Tiemeier H., Bultmann U., Snieder H., et al., "Bivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression", MOLECULAR PSYCHIATRY, cilt.25, sa.7, ss.1420-1429, 2020
dc.identifier.issn1359-4184
dc.identifier.otherav_5da9a832-8314-44bc-9071-99010351ed2d
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/4336
dc.identifier.urihttps://doi.org/10.1038/s41380-018-0336-6
dc.description.abstractAlthough a genetic basis of depression has been well established in twin studies, identification of genome-wide significant loci has been difficult. We hypothesized that bivariate analyses of findings from a meta-analysis of genome-wide association studies (meta-GWASs) of the broad depression phenotype with those from meta-GWASs of self-reported and recurrent major depressive disorder (MDD), bipolar disorder and schizophrenia would enhance statistical power to identify novel genetic loci for depression. LD score regression analyses were first used to estimate the genetic correlations of broad depression with self-reported MDD, recurrent MDD, bipolar disorder and schizophrenia. Then, we performed four bivariate GWAS analyses. The genetic correlations (r(g) +/- SE) of broad depression with self-reported MDD, recurrent MDD, bipolar disorder and schizophrenia were 0.79 +/- 0.07, 0.24 +/- 0.08, 0.53 +/- 0.09 and 0.57 +/- 0.05, respectively. From a total of 20 independent genome-wide significant loci, 13 loci replicated of which 8 were novel for depression. These wereMUC21for the broad depression phenotype with self-reported MDD andZNF804A,MIR3143,PSORS1C2,STK19,SPATA31D1,RTN1andTCF4for the broad depression phenotype with schizophrenia. Post-GWAS functional analyses of these loci revealed their potential biological involvement in psychiatric disorders. Our results emphasize the genetic similarities among different psychiatric disorders and indicate that cross-disorder analyses may be the best way forward to accelerate gene finding for depression, or psychiatric disorders in general.
dc.language.isoeng
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectBiochemistry, Genetics and Molecular Biology (miscellaneous)
dc.subjectClinical Biochemistry
dc.subjectCancer Research
dc.subjectMolecular Biology
dc.subjectDevelopmental Neuroscience
dc.subjectDrug Discovery
dc.subjectSitogenetik
dc.subjectAging
dc.subjectCellular and Molecular Neuroscience
dc.subjectCognitive Neuroscience
dc.subjectGeneral Biochemistry, Genetics and Molecular Biology
dc.subjectBiochemistry
dc.subjectGeneral Neuroscience
dc.subjectNeuroscience (miscellaneous)
dc.subjectSensory Systems
dc.subjectStructural Biology
dc.subjectHuman-Computer Interaction
dc.subjectPsychiatric Mental Health
dc.subjectPsychiatry and Mental Health
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectNEUROSCIENCES
dc.subjectSinirbilim ve Davranış
dc.subjectPsikiyatri
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.titleBivariate genome-wide association analyses of the broad depression phenotype combined with major depressive disorder, bipolar disorder or schizophrenia reveal eight novel genetic loci for depression
dc.typeMakale
dc.relation.journalMOLECULAR PSYCHIATRY
dc.contributor.departmentUniversity of Groningen , ,
dc.identifier.volume25
dc.identifier.issue7
dc.identifier.startpage1420
dc.identifier.endpage1429
dc.contributor.firstauthorID2390837


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