dc.contributor.author | Ghanadan, Alireza | |
dc.contributor.author | Soluk-Tekkesin, Merva | |
dc.contributor.author | Ghorbanpour, Maedeh | |
dc.contributor.author | Mahdavi, Nazanin | |
dc.contributor.author | Nabiyi, Parisa | |
dc.contributor.author | Aminishakib, Pouyan | |
dc.date.accessioned | 2021-03-02T17:42:51Z | |
dc.date.available | 2021-03-02T17:42:51Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mahdavi N., Aminishakib P., Nabiyi P., Ghanadan A., Ghorbanpour M., Soluk-Tekkesin M., "Evaluation of the presence of myofibroblasts and matrix metalloproteinase 1 expression in the stroma of oral verrucous hyperplasia and verrucous carcinoma", INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, cilt.63, ss.369-375, 2020 | |
dc.identifier.issn | 0377-4929 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_90b56fa1-a58f-4141-bc9f-cd45e6c11484 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/4321 | |
dc.identifier.uri | https://doi.org/10.4103/ijpm.ijpm_548_19 | |
dc.description.abstract | Background: Oral verrucous carcinoma is a low-grade subtype of oral squamous cell carcinoma that should be differentiated from oral verrucous hyperplasia, a premalignant lesion. Stromal activated myofibroblasts known as cancer-associated fibroblasts have an active role in the initiation and progression of the cancers via secretion of different molecules including matrix metalloproteinases. Aims: This study is designed to understand the differences in the presence of myofibroblasts and expression of matrix metalloproteinase-1 in the adjacent stroma of verrucous carcinoma and oral verrucous hyperplasia (OVH). Settings and Design: Cross-sectional study. Material and Methods: Twenty-seven OVH, 19 oral verrucous carcinoma (OVC), and 8 cutaneous verrucous carcinoma (CVC) specimens were analyzed for immunohistochemical (IHC) expression of alpha-smooth muscle actin (alpha SMA) and MMP-1. Results: IHC studies for alpha SMA expression in nonvascular stromal cells of the adjacent stroma revealed mild or no expression in 81.4%, 73.7%, and 62.5% of the cases of OVH, OVC, and CVC groups, respectively. No significant difference was seen in alpha SMA expression index between OVH and OVC groups (Adj. Sig. = 0.220) and between OVC and CVC groups (Adj. Sig. = 1.00). Pairwise analysis revealed a significant difference in MMP-1 expression index between the groups. No significant correlation was observed between MMP-1 expression index and aSMA expression index in OVH (pv = 0.358) and OVC (pv = 0.388) groups. Conclusion: The differences in MMP-1 expression between OVH and OVC can be used as an adjunctive aid in challenging cases including disoriented or inadequate samples. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | PATOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Patoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Temel Bilimler | |
dc.title | Evaluation of the presence of myofibroblasts and matrix metalloproteinase 1 expression in the stroma of oral verrucous hyperplasia and verrucous carcinoma | |
dc.type | Makale | |
dc.relation.journal | INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY | |
dc.contributor.department | Tehran University Of Medical Sciences , , | |
dc.identifier.volume | 63 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 369 | |
dc.identifier.endpage | 375 | |
dc.contributor.firstauthorID | 2263562 | |