TTF-l EXPRESSION IN SMALL CELL NEUROENDOCRINE CARCINOMAS OF THE LARYNX

Abstract

Small cell neuroendocrine carcinomas of the larynx are uncommon neoplasms-Differential diagnosis includes a limited variety of tumors such as typical carcinoid and atypical carcinoid tumors of the larynx and metastatic small cell lung carcinomas-In this study, 4 cases ol laryngeal small cell carcinoma ol neuroendocrine type were studied for morphological and immunohistochemical features. Three primary laryngeal small cell carcinomas-as well as one metastatic small cell lung carcinoma were detected to be immunopositive for TTF-1. Considering literature data and our findings, the value of TIF-1 expression was found to be questionable in the differential diagnosis between primary and metastatic small cell carcinomas of the larynx.