Basit öğe kaydını göster

dc.contributor.authorYilmazer, Selma
dc.contributor.authorErensoy, Neslihan
dc.contributor.authorCagatay, PENBE
dc.date.accessioned2021-03-03T14:15:18Z
dc.date.available2021-03-03T14:15:18Z
dc.date.issued2005
dc.identifier.citationErensoy N., Cagatay P., Yilmazer S., "Effects of estrogen and tamoxifen on the ultrastructural characteristics of female rat prolactin cells as evaluated by immunogold technique", ACTA HISTOCHEMICA, cilt.107, sa.3, ss.199-205, 2005
dc.identifier.issn0065-1281
dc.identifier.otherav_38907932-9916-465b-b629-2278882750b9
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/42097
dc.identifier.urihttps://doi.org/10.1016/j.acthis.2005.03.003
dc.description.abstractEstrogens and antiestrogens are known to have effects on protactin (PRL)-producing cells in the anterior pituitary. This study was planned to investigate the effects of estrogen and tamoxifen at immunohistochemical. and immunoelectron microscopic levels on PRL cells of female rat pituitary. Animals were divided into three groups of eight adult female rats each. The first group was the control. group. 200-mu g/day of estrogen was administered subcutaneously for 11 weeks to 16 rats. Tamoxifen was administered to eight of them for the Last 15 days. In diethylstilbestrol (DES)-induced group, serum PRL levels and pituitary weights were found to be elevated when compared with the control group. In the DES plus tamoxifen group the readings were close to that of the control group. PRL-positive cells were enlarged and strongly immunostained in DES-induced group when assessed by tight microscopy. Tamoxifen prevented this effect. At the ultrastructural. level., in the tamoxifen treated group, PRL-producing cells contained both immunopositive and immunonegative secretory granules. Numerous PRL-producing cells exhibited progressive morphological changes in the nuclei compatible with the apoptotic process. The results of this study indicate that tamoxifen prevents not only the proliferative effect of estrogen but also inhibits the secretion mechanism of the cells. (c) 2005 Elsevier GmbH. ALL rights reserved.
dc.language.isoeng
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectTemel Bilimler
dc.subjectTemel Tıp Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectHistoloji-Embriyoloji
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectHÜCRE BİYOLOJİSİ
dc.titleEffects of estrogen and tamoxifen on the ultrastructural characteristics of female rat prolactin cells as evaluated by immunogold technique
dc.typeMakale
dc.relation.journalACTA HISTOCHEMICA
dc.contributor.departmentİstanbul Üniversitesi , Cerrahpaşa Tıp Fakültesi , Temel Tıp Bilimleri Bölümü
dc.identifier.volume107
dc.identifier.issue3
dc.identifier.startpage199
dc.identifier.endpage205
dc.contributor.firstauthorID6358


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster