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Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate

dc.contributor.authorAltun, Seyhan
dc.contributor.authorBugan, Ilknur
dc.contributor.authorKucuk, Selma
dc.contributor.authorKaragoz, Zeynep
dc.contributor.authorFRASER, Scott P.
dc.contributor.authorKAYA, HANDAN
dc.contributor.authorDODSON, Andrew
dc.contributor.authorFOSTER, Christopher S.
dc.contributor.authorDJAMGOZ, Mustafa B. A.
dc.date.accessioned2021-03-03T13:25:31Z
dc.date.available2021-03-03T13:25:31Z
dc.date.issued2019
dc.identifier.citationBugan I., Kucuk S., Karagoz Z., FRASER S. P. , KAYA H., DODSON A., FOSTER C. S. , Altun S., DJAMGOZ M. B. A. , "Anti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate", PROSTATE CANCER AND PROSTATIC DISEASES, cilt.22, sa.4, ss.569-579, 2019
dc.identifier.issn1365-7852
dc.identifier.otherav_33f78707-f51d-4abf-b7a8-63a0e51193a3
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/39153
dc.identifier.urihttps://doi.org/10.1038/s41391-019-0128-3
dc.description.abstractBackground Voltage-gated Na+ channels (VGSCs) are functionally upregulated in rat and human prostate cancer (PCa) where channel activity promotes cellular invasiveness in vitro and metastasis in vivo. Ranolazine is a clinically used VGSC inhibitor/anti-anginal drug, which has been shown previously to inhibit breast cancer metastasis in vivo.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectÜROLOJİ VE NEFROLOJİ
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectİç Hastalıkları
dc.subjectONKOLOJİ
dc.subjectKlinik Tıp
dc.subjectDahili Tıp Bilimleri
dc.subjectOnkoloji
dc.subjectNefroloji
dc.titleAnti-metastatic effect of ranolazine in an in vivo rat model of prostate cancer, and expression of voltage-gated sodium channel protein in human prostate
dc.typeMakale
dc.relation.journalPROSTATE CANCER AND PROSTATIC DISEASES
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume22
dc.identifier.issue4
dc.identifier.startpage569
dc.identifier.endpage579
dc.contributor.firstauthorID82250


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