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dc.contributor.authorTerzioglu, T
dc.contributor.authorTezelman, S
dc.contributor.authorYalti, T
dc.date.accessioned2021-03-03T12:41:44Z
dc.date.available2021-03-03T12:41:44Z
dc.date.issued1997
dc.identifier.citationTerzioglu T., Yalti T., Tezelman S., "The effect of prostaglandin E-1 on experimental colitis in the rat", INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, cilt.12, sa.2, ss.63-66, 1997
dc.identifier.issn0179-1958
dc.identifier.otherav_2f82f7ea-6ef0-4e53-b0ef-9d4e397c4f8f
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/36463
dc.identifier.urihttps://doi.org/10.1007/s003840050082
dc.description.abstractProstaglandin E-1 (PGE(1)) is known to have a strong vasodilator effect and to block coagulation and inflammation in high concentrations. The aim of this study has been to investigate whether PGE(1) has an inhibitory effect on inflammation in experimental colitis. Experimental colitis was produced by rectal instillation of 10% acetic acid in 60 rats. These were divided into prostaglandin (PG) (n = 30) and control groups (n = 30). Twelve hours later, an intraperitoneal injection of 2 mu g PGE(1) in 1 ml saline was given to the PG group and 1 ml saline to the control group. This was repeated daily and the animals were sacrified in groups of 10 on the 3rd, 7th and 10th day. Histopathological examination and hydroxyproline determination for assessment of collagen synthesis were performed. PGE(1) significantly decreased inflammation on third day with the hydroxyproline level significantly higher in the PG group compared with the control group (p < 0.05). This difference was however not significant at the 7th and 10th day. The present study supports a beneficial role for prostaglandin E-1 in reducing the severity of colonic inflammation following chemically induced colitis but only in the early stages of development.
dc.language.isoeng
dc.subjectGastroenteroloji-(Hepatoloji)
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectİç Hastalıkları
dc.subjectDahili Tıp Bilimleri
dc.subjectTıp
dc.subjectCERRAHİ
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectGASTROENTEROLOJİ VE HEPATOLOJİ
dc.titleThe effect of prostaglandin E-1 on experimental colitis in the rat
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF COLORECTAL DISEASE
dc.contributor.department, ,
dc.identifier.volume12
dc.identifier.issue2
dc.identifier.startpage63
dc.identifier.endpage66
dc.contributor.firstauthorID118659


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