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dc.contributor.authorBolkent, Şehnaz
dc.contributor.authorTurkyilmaz, Ismet Burcu
dc.contributor.authorPirincci, Pelin Arda
dc.contributor.authorYanardag, Refiye
dc.date.accessioned2021-03-03T12:23:56Z
dc.date.available2021-03-03T12:23:56Z
dc.date.issued2019
dc.identifier.citationTurkyilmaz I. B. , Pirincci P. A. , Bolkent Ş., Yanardag R., "The effects of vitamins and selenium mixture or ranitidine against small intestinal injury induced by indomethacin in adult rats.", Journal of food biochemistry, cilt.43, sa.4, 2019
dc.identifier.issn0145-8884
dc.identifier.otherav_2dd2bd78-a6b8-44a9-9fe6-3e51442e86a5
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/35395
dc.identifier.urihttps://doi.org/10.1111/jfbc.12808
dc.description.abstractThis study was aimed at investigating morphological and biochemical efficacies of antioxidants on indomethacin-induced small intestinal damage in rats. Group I: control animals (negative control) given only placebo, Group II: (positive control) are animals orally given combination of antioxidants [vitamin C (Vit C), vitamin E (Vit E), beta-carotene and sodium selenite (Se)] daily for 3 days, Group III: Rats were given only indomethacin, Group IV: animals were given of antioxidants combination for 3 days, last dose was given 2 hr before the administration of indomethacin. Group V: Animals receiving ranitidine for 3 days (second positive control). Group VI: Animals received ranitidine for 3 days, last dose was given 2 hr before to indomethacin administration. Indomethacin caused degenerative morphological and biochemical changes, which were reversed on antioxidants administration. As a result, we propose that antioxidants combination would be therapeutically beneficial for treating indomethacin-induced lesions of small intestine. Practical applications Indomethacin is a widely preferred nonsteroidal anti-inflammatory drug (NSAID) but its side effects on gastrointestinal system are well known. Indomethacin also causes production of reactive oxygen species. Antioxidants and selenium has protective effects. According to the results of this study, antioxidants and selenium can be used as a food supplement for preventing NSAID-induced side effects and toxicity.
dc.language.isoeng
dc.subjectGıda Mühendisliği
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectTarım Bilimleri
dc.subjectGIDA BİLİMİ VE TEKNOLOJİSİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleThe effects of vitamins and selenium mixture or ranitidine against small intestinal injury induced by indomethacin in adult rats.
dc.typeMakale
dc.relation.journalJournal of food biochemistry
dc.contributor.departmentİstanbul Üniversitesi , Mühendislik Fakültesi Kimya Bölümü , Kimya
dc.identifier.volume43
dc.identifier.issue4
dc.contributor.firstauthorID76593


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