dc.contributor.author | BLUEMER, Nicole | |
dc.contributor.author | DICKE, Tanja | |
dc.contributor.author | SEL, Serdar | |
dc.contributor.author | SEL, Sarper | |
dc.contributor.author | SZALAI, Krisztina | |
dc.contributor.author | KNITTELFELDER, Regina | |
dc.contributor.author | UNTERSMAYR, Eva | |
dc.contributor.author | SCHEINER, Otto | |
dc.contributor.author | GARN, Holger | |
dc.contributor.author | JENSEN-JAROLIM, Erika | |
dc.contributor.author | RENZ, Harald | |
dc.contributor.author | Ozdemir, Cevdet | |
dc.contributor.author | WEGMANN, Michael | |
dc.contributor.author | SCHOELL, Isabella | |
dc.contributor.author | ACKERMANN, Ute | |
dc.date.accessioned | 2021-03-03T12:23:22Z | |
dc.date.available | 2021-03-03T12:23:22Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | SCHOELL I., ACKERMANN U., Ozdemir C., BLUEMER N., DICKE T., SEL S., SEL S., WEGMANN M., SZALAI K., KNITTELFELDER R., et al., "Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring", FASEB JOURNAL, cilt.21, sa.4, ss.1264-1270, 2007 | |
dc.identifier.issn | 0892-6638 | |
dc.identifier.other | av_2dc131ca-52c6-4022-b10d-ed19145b17b6 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/35350 | |
dc.identifier.uri | https://doi.org/10.1096/fj.06-7223com | |
dc.description.abstract | The treatment of dyspeptic disorders with anti-acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30-50% of pregnant women due to reflux and heartburn, we aimed here to investigate the impact of maternal therapy with anti-acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti-acid drug, to pregnant BALB/c mice during pregnancy and lactation. These mothers developed a codfish-specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensitization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these offspring we found a relative Th2-dominance, because the Th1- and T-regulatory cytokines were significantly suppressed. Our data provide evidence that the anti-acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2-milieu in their offspring. From these results we propose that anti-acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants. | |
dc.language.iso | eng | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | BİYOLOJİ | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyokimya | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Tıbbi Biyoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.title | Anti-ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2-bias in their offspring | |
dc.type | Makale | |
dc.relation.journal | FASEB JOURNAL | |
dc.contributor.department | , , | |
dc.identifier.volume | 21 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 1264 | |
dc.identifier.endpage | 1270 | |
dc.contributor.firstauthorID | 104491 | |