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dc.contributor.authorERKUTLU, İBRAHİM
dc.contributor.authorPENÇE, Sadrettin
dc.contributor.authorALPTEKİN, MEHMET
dc.contributor.authorBOSNAK, MEHMET
dc.contributor.authorKURTUL, NACİYE
dc.contributor.authorTan, Uener
dc.date.accessioned2021-03-03T11:48:40Z
dc.date.available2021-03-03T11:48:40Z
dc.date.issued2009
dc.identifier.citationPENÇE S., ERKUTLU İ., KURTUL N., BOSNAK M., ALPTEKİN M., Tan U., "Antiepileptogenic Effects of Glutathione Against Increased Brain ADA in PTZ-Induced Epilepsy", INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.119, sa.5, ss.616-629, 2009
dc.identifier.issn0020-7454
dc.identifier.othervv_1032021
dc.identifier.otherav_2a1a437c-0d5c-4981-bfb7-f710cb1e2c78
dc.identifier.urihttp://hdl.handle.net/20.500.12627/33094
dc.identifier.urihttps://doi.org/10.1080/00207450802055440
dc.description.abstractAdenosine has been shown to play a significant role as a modulator of neuronal activity in convulsive disorders, acting as an endogenous anticonvulsant agent. Any change in adenosine deaminase (ADA) levels will reflect to adenosine levels. In the present study, we have investigated the effect of glutathione on brain tissue ADA levels due to seizures induced by convulsive and subconvulsive dose of pentylenetetrazol (PTZ) in mice. ADA levels due to seizures induced by convulsive and subconvulsive pentylenetetrazol were measured using the Giusti method. ADA levels were higher in the experimental epilepsy groups than in the control and sham groups. ADA levels significantly decreased in the glutathione groups, which may have antiseizure effects. Decreased levels of ADA would be due to increased adenosine levels, protecting against oxidative stress.
dc.language.isoeng
dc.subjectSinirbilim ve Davranış
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectNEUROSCIENCES
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.titleAntiepileptogenic Effects of Glutathione Against Increased Brain ADA in PTZ-Induced Epilepsy
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF NEUROSCIENCE
dc.contributor.departmentÇukurova Üniversitesi , ,
dc.identifier.volume119
dc.identifier.issue5
dc.identifier.startpage616
dc.identifier.endpage629
dc.contributor.firstauthorID727272


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