dc.contributor.author | Turan, Suna Ozbas | |
dc.contributor.author | Ozar, Melek Ozlem Kolusayin | |
dc.contributor.author | Topcul, Mehmet Rıfkı | |
dc.contributor.author | Cetin, Idil | |
dc.date.accessioned | 2021-03-03T11:29:34Z | |
dc.date.available | 2021-03-03T11:29:34Z | |
dc.identifier.citation | Topcul M. R. , Cetin I., Turan S. O. , Ozar M. O. K. , "In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab-paclitaxel on triple-negative and luminal A breast cancer cells", ONCOLOGY REPORTS, cilt.40, ss.527-535, 2018 | |
dc.identifier.issn | 1021-335X | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_282d9de3-667f-4a40-a750-7391cbbeb2c7 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/31878 | |
dc.identifier.uri | https://doi.org/10.3892/or.2018.6364 | |
dc.description.abstract | In the present study, the in vitro cytotoxic effect of poly(ADP-ribose) polymerase (PARP) inhibitor alone and in combination with nab-paclitaxel was evaluated on human triple-negative breast cancer (TNBC) cell line MDA-MB-231 and human luminal A breast cancer cell line MCF-7. For this purpose, cell index (CI) values obtained from xCELLigence Real-Time Cell Analysis (RTCA) DP instrument, mitotic index (MI), labelling index (LI) and apoptotic index (AI) analysis among cell kinetic parameters were used. As a result of PARP inhibitor application, there was a significant decrease in CI, MI and LI and a significant increase in AI for all the experimental groups. After application of PARP inhibitor in combination with nab-paclitaxel, the CI values were decreased for both cell lines, and the differences between the control and all the experimental groups were statistically significant (P<0.01) for all applications. PARP inhibitor, alone or in combination with nab-paclitaxel offers a promising treatment modality in different breast cancer subtypes. | |
dc.language.iso | eng | |
dc.subject | Onkoloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | İç Hastalıkları | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | In vitro cytotoxic effect of PARP inhibitor alone and in combination with nab-paclitaxel on triple-negative and luminal A breast cancer cells | |
dc.type | Makale | |
dc.relation.journal | ONCOLOGY REPORTS | |
dc.contributor.department | Marmara Üniversitesi , , | |
dc.identifier.volume | 40 | |
dc.identifier.startpage | 527 | |
dc.identifier.endpage | 535 | |
dc.contributor.firstauthorID | 806337 | |