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Full automation of Ga-68 labelling of DOTA-peptides including cation exchange prepurification

dc.contributor.authorPetrik, M.
dc.contributor.authorOcak, M.
dc.contributor.authorKunkel, F.
dc.contributor.authorDecristoforo, C.
dc.contributor.authorBergisadi, N.
dc.contributor.authorAntretter, M.
dc.contributor.authorKnopp, R.
dc.date.accessioned2021-03-03T11:13:57Z
dc.date.available2021-03-03T11:13:57Z
dc.date.issued2010
dc.identifier.citationOcak M., Antretter M., Knopp R., Kunkel F., Petrik M., Bergisadi N., Decristoforo C., "Full automation of Ga-68 labelling of DOTA-peptides including cation exchange prepurification", APPLIED RADIATION AND ISOTOPES, cilt.68, sa.2, ss.297-302, 2010
dc.identifier.issn0969-8043
dc.identifier.othervv_1032021
dc.identifier.otherav_26bc469a-ec0e-4d7b-b39e-eb0c7dc47542
dc.identifier.urihttp://hdl.handle.net/20.500.12627/30905
dc.identifier.urihttps://doi.org/10.1016/j.apradiso.2009.10.006
dc.description.abstractHere we describe a fully automated approach for the synthesis of Ga-68-labelled DOTA-peptides based on pre-concentration and purification of the generator eluate by using a cation exchange-cartridge and its comparison with fully automated direct labelling applying fractionated elution. Pre-concentration of the eluate on a cation exchange cartridge both using a resin-based and a disposable cation-exchange cartridge efficiently removed Ge-68 as well as major metal contaminations with Fe and Zn. This resulted in a high labelling efficiency of DOTA-peptides at high specific activity (SA) with short synthesis times. (C) 2009 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectNükleer Tıp
dc.subjectNükleer Fizik
dc.subjectİnorganik Kimya
dc.subjectTemel Bilimler
dc.subjectRADYOLOJİ, NÜKLEER TIP ve MEDİKAL GÖRÜNTÜLEME
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectFizik
dc.subjectNÜKLEAR BİLİMİ VE TEKNOLOJİSİ
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, İNORGANİK VE NÜKLEER
dc.titleFull automation of Ga-68 labelling of DOTA-peptides including cation exchange prepurification
dc.typeMakale
dc.relation.journalAPPLIED RADIATION AND ISOTOPES
dc.contributor.departmentMedical University of Innsbruck , ,
dc.identifier.volume68
dc.identifier.issue2
dc.identifier.startpage297
dc.identifier.endpage302
dc.contributor.firstauthorID195095


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