dc.contributor.author | Gokbuget, A | |
dc.contributor.author | Olsen, I | |
dc.contributor.author | Griffiths, G | |
dc.contributor.author | Newman, HN | |
dc.contributor.author | Porter, SR | |
dc.contributor.author | Kirby, AC | |
dc.date.accessioned | 2021-03-03T11:12:41Z | |
dc.date.available | 2021-03-03T11:12:41Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | Kirby A., Griffiths G., Gokbuget A., Newman H., Porter S., Olsen I., "Localized adhesion molecule expression and circulating LFA-3 levels in adult and early onset forms of periodontitis", JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.26, sa.12, ss.793-801, 1999 | |
dc.identifier.issn | 0303-6979 | |
dc.identifier.other | av_269742a9-3e00-4b14-b5c3-495133c43731 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/30815 | |
dc.identifier.uri | https://doi.org/10.1111/j.1600-051x.1999.tb02522.x | |
dc.description.abstract | Because of their importance in mediating cellular interactions in chronic inflammatory diseases, this study has examined the expression of a number of adhesion molecules in adult (n=11), generalized early onset (n=5) and localized early onset (n=2) forms of periodontitis. In comparison with immunostaining profiles of cryostat sections of healthy gingival tissue (n=7), the beta 1 integrins VLA-I, VLA-2 and VLA-4 were found to be up-regulated in periodontitis, with VLA-6 being markedly elevated. Although only small differences were observed in ICAM-1 and LFA-3 expression in the gingival epithelium, there was particularly notable up-regulation of these adhesion molecules within the inflammatory infiltrates of the diseased tissues. However, there were no statistically significant differences between the serum levels of a soluble form of LFA-3 in periodontitis patients (n=47) compared with healthy control subjects (n=40), although the generalized early onset and adult periodontitis groups exhibited wider ranges of circulating LFA-3. These findings show that there is localized modulation of adhesion molecule expression in the chronic inflammatory periodontal diseases studied, but that the levels of LFA-3 in the circulation nevertheless remain unaffected. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Sağlık Bilimleri | |
dc.subject | DİŞ HEKİMLİĞİ, ORAL CERRAHİ VE TIP | |
dc.subject | Klinik Tıp | |
dc.subject | Tıp | |
dc.subject | Diş Hekimliği | |
dc.title | Localized adhesion molecule expression and circulating LFA-3 levels in adult and early onset forms of periodontitis | |
dc.type | Makale | |
dc.relation.journal | JOURNAL OF CLINICAL PERIODONTOLOGY | |
dc.contributor.department | , , | |
dc.identifier.volume | 26 | |
dc.identifier.issue | 12 | |
dc.identifier.startpage | 793 | |
dc.identifier.endpage | 801 | |
dc.contributor.firstauthorID | 124369 | |