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dc.contributor.authorDogru-Abbasoglu, Semra
dc.contributor.authorOZDERYA, Aysenur
dc.contributor.authorKARADAG, Berrin
dc.contributor.authorAkman, Fevziye Emin
dc.contributor.authorKanmaz-Ozer, Muge
dc.contributor.authorUysal, Mujdat
dc.contributor.authorVural, Pervin
dc.date.accessioned2021-03-03T10:28:08Z
dc.date.available2021-03-03T10:28:08Z
dc.date.issued2012
dc.identifier.citationAkman F. E. , Kanmaz-Ozer M., Vural P., OZDERYA A., KARADAG B., Dogru-Abbasoglu S., Uysal M., "G241R and K469E polymorphisms of intercellular adhesion molecule 1 (ICAM-1) could predispose to Hashimoto thyroiditis", MOLECULAR BIOLOGY REPORTS, cilt.39, sa.12, ss.10723-10729, 2012
dc.identifier.issn0301-4851
dc.identifier.othervv_1032021
dc.identifier.otherav_22c2924b-032b-422c-970a-49c34621e1d8
dc.identifier.urihttp://hdl.handle.net/20.500.12627/28369
dc.identifier.urihttps://doi.org/10.1007/s11033-012-1963-7
dc.description.abstractThis study examined firstly the possible association of G241R and K469E single nucleotide polymorphisms (SNPs) of ICAM-1 gene with the occurrence of Hashimoto thyroiditis (HT). G241R and K469E SNPs in DNA from peripheral blood leukocytes of 190 HT and 247 healthy controls were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. There was a significant increase of ICAM-1 241R allele frequency in patients with HT compared with healthy controls (P = 0.04, OR = 1.84, 95 % CI = 1.00-3.37). Regarding ICAM-1 K469E polymorphism, patients homozygous for E allele had 1.73-fold increased risk for developing HT according to KK homozygotes (P = 0.04, 95 % CI = 1.00-3.01). The 469E allele frequency was higher in HT patients according to controls, however the difference was at borderline significance (P = 0.05, OR = 1.30, 95 % CI = 1.00-1.70). No associations between polymorphisms and HT phenotypes were observed. We suggest that the G241R and K469E SNPs of ICAM-1 gene may be related to occurrence of HT. However, more studies with larger sample size including other loci of the ICAM-1 gene are necessary to support our findings before any definite statement can be made about the relationship between HT and ICAM-1 polymorphism.
dc.language.isoeng
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectSitogenetik
dc.subjectTemel Bilimler
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.titleG241R and K469E polymorphisms of intercellular adhesion molecule 1 (ICAM-1) could predispose to Hashimoto thyroiditis
dc.typeMakale
dc.relation.journalMOLECULAR BIOLOGY REPORTS
dc.contributor.departmentIstanbul Sisli Hamidiye Etfal Training & Research Hospital , ,
dc.identifier.volume39
dc.identifier.issue12
dc.identifier.startpage10723
dc.identifier.endpage10729
dc.contributor.firstauthorID44587


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