dc.contributor.author | AKKUS, S | |
dc.contributor.author | KASAPCOPUR, O | |
dc.contributor.author | Caliskan, Salim | |
dc.date.accessioned | 2021-03-03T09:59:17Z | |
dc.date.available | 2021-03-03T09:59:17Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | AKKUS S., Caliskan S., KASAPCOPUR O., "Tubular functions in familial Mediterranean fever", TURKISH JOURNAL OF PEDIATRICS, cilt.44, sa.4, ss.317-320, 2002 | |
dc.identifier.issn | 0041-4301 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_200994c0-a45a-4a2a-8669-407c96ff889f | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/26627 | |
dc.description.abstract | In this study, we aimed to evaluate renal tubular function in familial Mediterranean fever (FMF). Urinary N-acetyl-beta-D glucosaminidase (U-NAG, beta(2)-microglobulin (U-beta(2)M) and microalbumin (Ua) levels were measured in children with different clinical stages of FMF (58 patients with FMF, 9 patients with amyloidosis secondary to (FMF). Control groups were healthy children (n=21), children with upper respiratory tract infection (URTI) (n=21) and with steroid sensitive nephrotic syndrome (SSNS) (n=18). U-NAG was significantly increased in patients with a recent diagnosis of FMF compared to patients with FMF on colchicine and to healthy controls. in patients with recently diagnosed FMF, a marked decrease in U-NAG, U-beta(2)M and Ua were determined after three months on colchicine therapy. On the other hand, U-NAG and Ubeta(2)M levels were increased in patients with FMF during attacks and then decreased in the post-attack period. U-beta(2)M in patients with FMF during attacks was significantly different from patients with URTI. Finally, U-NAG and U-beta(2)M were increased significantly in patients with FMF-amyloidosis and SSNS when compared with other FMF groups and healthy controls, respectively. In conclusion, the high U-NAG value in newly diagnosed patients compared to that of patients taking colchicine and the decline of U-NAG and U-beta(2)M levels after attack to the levels observed in colchicine users (without a significant change in Ua value) suggest that the renal injury early in the course of FMF might be dominantly at the level of the tubuli. | |
dc.language.iso | eng | |
dc.subject | Tıp | |
dc.subject | Çocuk Sağlığı ve Hastalıkları | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | PEDİATRİ | |
dc.title | Tubular functions in familial Mediterranean fever | |
dc.type | Makale | |
dc.relation.journal | TURKISH JOURNAL OF PEDIATRICS | |
dc.contributor.department | İstanbul Üniversitesi , , | |
dc.identifier.volume | 44 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 317 | |
dc.identifier.endpage | 320 | |
dc.contributor.firstauthorID | 13251 | |