Basit öğe kaydını göster

dc.contributor.authorUzun, Hafize
dc.contributor.authorCengiz, Mahir
dc.contributor.authorYavuzer, Serap
dc.contributor.authorYavuzer, Hakan
dc.contributor.authorDoventas, Alper
dc.contributor.authorBalci, Huriye
dc.contributor.authorErdincler, Deniz Suna
dc.contributor.authorErman, Hayriye
dc.date.accessioned2021-03-03T08:40:14Z
dc.date.available2021-03-03T08:40:14Z
dc.date.issued2016
dc.identifier.citationYavuzer H., Yavuzer S., Cengiz M., Erman H., Doventas A., Balci H., Erdincler D. S. , Uzun H., "Biomarkers of lipid peroxidation related to hypertension in aging", HYPERTENSION RESEARCH, cilt.39, sa.5, ss.342-348, 2016
dc.identifier.issn0916-9636
dc.identifier.otherav_18c4b407-1d06-4f2c-a848-cae5d13a1b6c
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/21983
dc.identifier.urihttps://doi.org/10.1038/hr.2015.156
dc.description.abstractThe aim of this clinical study was to evaluate the influence of aging on the levels of lipid peroxidation (quantified as thiobarbituric acid-reactive substances (TBARS) content), lipid hydroperoxide (LOOH), hexanoyl lysine (HEL), 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) and total antioxidant capacity (TAC), and determine their relationships to the demographic and cardiovascular risk factors in elderly hypertensive (HT) patients. This study consisted of four groups: two elderly groups with 30 HT patients (11 males, 19 females) and 30 normotensive healthy volunteers (15 males, 15 females), and two young groups with 30 HT patients (13 males, 17 females) and 30 normotensive healthy volunteers (12 males, 18 females). In the elderly control group, the TBARS, LOOH, HEL and 8-iso-PGF2 alpha levels, and the carotid intima media thickness (CIMT) were significantly higher than in the young control group. The TBARS, LOOH, HEL and 8-iso-PGF2 alpha levels and the CIMT measurements were significantly higher in the elderly HT group than in the young HT group. In addition, the TAC levels were significantly lower in the elderly and young HT groups than in the elderly and young control groups. The CIMT was significantly positively correlated with TBARS (r=0.40, P<0.001), HEL (r= 0.30, P=0.001), LOOH (r= 0.44, P<0.001) and 8-iso-PGF2 alpha (r=0.32, P<0.001) in all of the HT groups. It seems that in elderly patients, the LOOH and TBARS are better biomarkers of lipid peroxidation in hypertension in terms of sensitivity. In all of the HT groups, 8-iso-PGF2 alpha had the highest sensitivity. Hypertension is associated with lipid peroxidation due to an impaired oxidant/antioxidant status. Increased lipid peroxidation and decreased antioxidants with aging indicate that peroxidative damage further increases with higher blood pressure and the aging process.
dc.language.isoeng
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.titleBiomarkers of lipid peroxidation related to hypertension in aging
dc.typeMakale
dc.relation.journalHYPERTENSION RESEARCH
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume39
dc.identifier.issue5
dc.identifier.startpage342
dc.identifier.endpage348
dc.contributor.firstauthorID19377


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster