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dc.contributor.authorÖKTEM, GÜLPERİ
dc.contributor.authorBilir, Ayhan
dc.contributor.authorKara, Ali Nail
dc.contributor.authorERGÜVEN, MİNE
dc.date.accessioned2021-03-03T08:39:44Z
dc.date.available2021-03-03T08:39:44Z
dc.date.issued2016
dc.identifier.citationERGÜVEN M., ÖKTEM G., Kara A. N. , Bilir A., "Lithium chloride has a biphasic effect on prostate cancer stem cells and a proportional effect on midkine levels", ONCOLOGY LETTERS, cilt.12, sa.4, ss.2948-2955, 2016
dc.identifier.issn1792-1074
dc.identifier.otherav_18b5a6cd-267c-4118-95fe-83529214c4b0
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/21945
dc.identifier.urihttps://doi.org/10.3892/ol.2016.4946
dc.description.abstractProstate cancer (PCa) is the second most frequent type of cancer in men worldwide and the levels of differentiation growth factor midkine (MK) are increased in PCa. Cancer and/or the treatment process itself may lead to psychiatric disorders. Lithium chloride (LiCl) has anti-manic properties and has been used in cancer therapy; however, it has a queried safety profile. In addition, cancer stem cells are responsible for the heterogeneous phenotype of tumor cells; they are involved in progression, metastasis, recurrence and therapy resistance in various cancer types. The aims of the present study were to investigate the effect of different concentrations of LiCl on PCa stem cells (whether a shift from tumorigenic to non-tumorigenic cells occurs) and to determine if these results can be explained through changes in MK levels. Monolayer and spheroid cultures of human prostate stem cells and non-stem cells were incubated with low (1, 10 mu M) and high (100, 500 mu M) concentrations of LiCl for 72 h. Cell proliferation, apoptotic indices, MK levels and ultrastructure were evaluated. Cells stimulated with low concentrations showed high proliferation, low apoptotic indices, high MK levels and more healthy ultrastructure. Opposite results were obtained at high concentrations. Furthermore, stem cells were more sensitive to stimulation and more resistant to inhibition than non-stem cells. LiCl exhibited concentration-dependent effects on stem cell and non-stem cell groups. MK levels were not involved in the biphasic effect of LiCl; however, they were proportionally affected. To the best of our knowledge, the present study was the first to show the effect of LiCl on PCa stem cells through MK.
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectOnkoloji
dc.subjectDahili Tıp Bilimleri
dc.subjectİç Hastalıkları
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectONKOLOJİ
dc.titleLithium chloride has a biphasic effect on prostate cancer stem cells and a proportional effect on midkine levels
dc.typeMakale
dc.relation.journalONCOLOGY LETTERS
dc.contributor.departmentİstanbul Aydın Üniversitesi , Sağlık Hizmetleri Meslek Yüksekokulu , Patoloji Laboratuvar Teknikleri Pr.
dc.identifier.volume12
dc.identifier.issue4
dc.identifier.startpage2948
dc.identifier.endpage2955
dc.contributor.firstauthorID235573


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