Basit öğe kaydını göster

dc.contributor.authorOzturk, M
dc.contributor.authorErensoy, Neslihan
dc.contributor.authorTanakol, Refik
dc.contributor.authorYilmazer, Selma
dc.contributor.authorDuman, BS
dc.date.accessioned2021-03-03T08:35:10Z
dc.date.available2021-03-03T08:35:10Z
dc.date.issued2004
dc.identifier.citationDuman B., Tanakol R., Erensoy N., Ozturk M., Yilmazer S., "Vitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women", MEDICAL PRINCIPLES AND PRACTICE, cilt.13, sa.5, ss.260-266, 2004
dc.identifier.issn1011-7571
dc.identifier.otherav_184fc1b2-11d8-4989-9d63-7b9a31e4d995
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/21662
dc.identifier.urihttps://doi.org/10.1159/000079524
dc.description.abstractObjective: Vitamin D receptor (VDR) gene polymorphisms and bone metabolic markers were investigated as potential genetic markers for osteoporosis in postmenopausal Turkish women. The relationship between their VDR gene polymorphisms and bone states was determined. Materials and Methods: Restriction fragment length polymorphisms at the VDR gene locus (i.e., for BsmI, ApaI, and TaqI) was investigated in 75 postmenopausal osteoporotic (53.16+/-1.31 years) and 66 healthy (52.62+/-1.69 years) Turkish women and the genotypes were related to bone mineral density (BMD) at femoral neck (FN), lumbar spine (L1-4), trochanter, Ward's triangle (Ward's) and metabolic parameters of bone turnover. Results: In osteoporotic women, TaqI genotype-related differences of the VDR gene were found to be significant at all BMD sites; TT genotype had higher L1-4 BMD values than Tt and tt (p<0.05); tt genotype had significantly lower BMD at FN (p<0.05), trochanter (p<0.01), and Ward's (p<0.05) compared to TT genotype. The tt genotype was found to be associated with higher (p<0.05) serum osteocalcin levels compared to Tt and TT genotypes in the osteoporotic women, whereas no such association was found for the healthy women. Conclusion: Our data showed an association between VDR TaqI genotype and BMD at the FN, L1-4, trochanter and Ward's triangle in nonobese postmenopausal osteoporotic women. Thus the VDR gene TaqI polymorphism modulates differences in BMD in the postmenopausal osteoporotic women. Copyright (C) 2004 S. Karger AG, Basel.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.subjectTIP, GENEL & İÇECEK
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectTemel Tıp Bilimleri
dc.titleVitamin D receptor alleles, bone mineral density and turnover in postmenopausal osteoporotic and healthy women
dc.typeMakale
dc.relation.journalMEDICAL PRINCIPLES AND PRACTICE
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume13
dc.identifier.issue5
dc.identifier.startpage260
dc.identifier.endpage266
dc.contributor.firstauthorID6338


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster