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dc.contributor.authorAvunduk, MC
dc.contributor.authorBaltaci, Ayşegül
dc.contributor.authorMogolkoc, R
dc.contributor.authorAvunduk, AM
dc.contributor.authorOzyazgan, Yılmaz
dc.contributor.authorOztekin, E
dc.date.accessioned2021-03-03T08:26:18Z
dc.date.available2021-03-03T08:26:18Z
dc.date.issued2004
dc.identifier.citationAvunduk M., Avunduk A., Oztekin E., Baltaci A., Ozyazgan Y., Mogolkoc R., "Etanercept treatment in the endotoxin-induced uveitis of rats", EXPERIMENTAL EYE RESEARCH, cilt.79, sa.3, ss.357-365, 2004
dc.identifier.issn0014-4835
dc.identifier.otherav_177b308d-f9e3-4e02-8935-e0da82f13f57
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/21146
dc.identifier.urihttps://doi.org/10.1016/j.exer.2004.06.001
dc.description.abstractThis study was conducted to investigate therapeutic value of a soluble tumor necrosis factor-alpha (TNF-alpha) receptor, etanercept, in a rat model of endotoxin-induced uveitis (EIU). Forty-two inbred male Lewis rats were divided into seven equal groups. 200 mug of Escherichia coli 055:1355 lipopolysaccharide, (LPS) was injected in one hind footpad of the Groups 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received subcutaneous etanercept 24 hr prior to LPS injection at a dose of 0(.)4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uvetis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized. Neutrophil leukocytes, CD8 +, CD4 +, and CD45RO + cells in the anterior uveal tissue were counted either after hematoxylin-eosin or monoclonal antibody staining. TNF-alpha. levels were also measured in the aqueous humor samples by an ELISA method. Etanercept treatment significantly improved clinical uveitis scores at all examination points compared to the LPS injected animals. The improvement was almost complete expect for the miosis score, since no significant difference was detected between the controls and LPS + Etanercept treated animals at all examination points. Cell counts were also at significantly lower levels in LPS + Etanercept treated animals at all examination points, except for CD8 + and CD45RO + cell counts at 24 hr examination point. There was no significant difference between the controls and LPS + Etanercept treated animals at all examination points as with CD4 + and CD45RO + cell counts at 48 hr. Our data showed that etanercept had a definite effect on the treatment of EIU. Further studies should clarify its efficacy on clinical uveitis conditions. (C) 2004 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.subjectGöz Hastalıkları ve Cerrahisi
dc.subjectCerrahi Tıp Bilimleri
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectOFTALMOLOJİ
dc.titleEtanercept treatment in the endotoxin-induced uveitis of rats
dc.typeMakale
dc.relation.journalEXPERIMENTAL EYE RESEARCH
dc.contributor.department, ,
dc.identifier.volume79
dc.identifier.issue3
dc.identifier.startpage357
dc.identifier.endpage365
dc.contributor.firstauthorID6649


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