dc.contributor.author | Karakus, Nevin | |
dc.contributor.author | Yigit, Serbulent | |
dc.contributor.author | Ozsoy, Asker Zeki | |
dc.contributor.author | Delibas, Ilhan Bahri | |
dc.contributor.author | KUNT İŞGÜDER, Çiğdem | |
dc.contributor.author | Dogru, Hatice Yilmaz | |
dc.date.accessioned | 2021-03-03T08:23:38Z | |
dc.date.available | 2021-03-03T08:23:38Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Dogru H. Y. , Ozsoy A. Z. , Karakus N., Delibas I. B. , KUNT İŞGÜDER Ç., Yigit S., "Association of Genetic Polymorphisms in TNF and MIF Gene with the Risk of Primary Dysmenorrhea", BIOCHEMICAL GENETICS, cilt.54, sa.4, ss.457-466, 2016 | |
dc.identifier.issn | 0006-2928 | |
dc.identifier.other | av_174621d2-3c4f-4261-8cca-49e9e8f8d162 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/21011 | |
dc.identifier.uri | https://doi.org/10.1007/s10528-016-9732-2 | |
dc.description.abstract | Primary dysmenorrhea, which affects 90 % of adolescent girls and more than 50 % of menstruating women worldwide, is characterized by recurrent pain during menses in the absence of a detectable organic disease. The aim of this study is to assess the association between MIF -173 and TNF -308 genetic polymorphisms and the clinical features of primary dysmenorrhea. The study population comprised 154 unrelated female patients with clinical diagnosis of dysmenorrhea, and a total of 144 control subjects were recruited consecutively. The MIF -173G > C promoter polymorphism (rs755622) and TNF gene -308G > A (rs1800629) polymorphism were analyzed by polymerase chain reaction-based restriction fragment length polymorphism assay. Two fragments (268 and 97 bp) were seen when the G allele was present at position -173, and three fragments (206, 97, and 62 bp) were observed when the C allele was present. Two fragments (87 and 20 bp) were seen when G allele was present at position -308. There were statistically significant associations between age at menarche and history of back pain among dysmenorrhea patients and MIF gene -173G > C polymorphism (p = 0.003 and p = 0.042, respectively). The genotype and allele frequencies of -308G > A polymorphism showed statistically significant differences between dysmenorrhea patients and controls (p = 0.023 and p = 0.009, respectively). A high association was also observed when the patients were compared with the controls according to the GG genotype versus GA+AA genotypes (p = 0.009). The present study showed that the TNF-alpha -308 GG genotype may be a useful tool to predict the susceptibility of dysmenorrhea. | |
dc.language.iso | eng | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Tıbbi Genetik | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Tıp | |
dc.subject | GENETİK VE HAYAT | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.title | Association of Genetic Polymorphisms in TNF and MIF Gene with the Risk of Primary Dysmenorrhea | |
dc.type | Makale | |
dc.relation.journal | BIOCHEMICAL GENETICS | |
dc.contributor.department | Tokat Gaziosmanpaşa Üniversitesi , , | |
dc.identifier.volume | 54 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 457 | |
dc.identifier.endpage | 466 | |
dc.contributor.firstauthorID | 2263490 | |