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dc.contributor.authorChalkiadaki, Christina
dc.contributor.authorAlegakis, Athanasios
dc.contributor.authorKalliantasi, Aikaterini
dc.contributor.authorTsatsakis, Aristidis
dc.contributor.authorCalina, Daniela
dc.contributor.authorKarzi, Vasiliki
dc.contributor.authorOzcagli, Eren
dc.contributor.authorTzatzarakis, Manolis N.
dc.contributor.authorVakonaki, Elena
dc.contributor.authorFragkiadoulaki, Irene
dc.contributor.authorDocea, Anca Oana
dc.contributor.authorMakrigiannakis, Antonios
dc.contributor.authorKarzi, Aikaterini
dc.contributor.authorStivaktakis, Polychronis
dc.date.accessioned2023-10-10T10:39:19Z
dc.date.available2023-10-10T10:39:19Z
dc.date.issued2023
dc.identifier.citationKarzi V., Ozcagli E., Tzatzarakis M. N., Vakonaki E., Fragkiadoulaki I., Kalliantasi A., Chalkiadaki C., Alegakis A., Stivaktakis P., Karzi A., et al., "DNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, sa.12, 2023
dc.identifier.issn1661-6596
dc.identifier.othervv_1032021
dc.identifier.otherav_09418588-55b7-4fec-b99e-78a0bd28bccd
dc.identifier.urihttp://hdl.handle.net/20.500.12627/189422
dc.identifier.urihttps://doi.org/10.3390/ijms24129989
dc.description.abstractExposure to chemical substances has always been a matter of concern for the scientific community. During the last few years, researchers have been focusing on studying the effects resulting from combined exposure to different substances. In this study, we aimed to determine the DNA damage caused after chronic and combined exposure to substances characterized as endocrine disruptors using comet and micronuclei assays, specifically glyphosate (pure and commercial form), bisphenol A, parabens (methyl-, propyl- and butylparaben), triclosan and bis (2-ethylhexyl) phthalate. The highest mean tail intensity was observed in the group exposed to a high-dose (10 x ADI) mixture of substances (Group 3), with a mean value of 11.97 (11.26-13.90), while statistically significant differences were noticed between the groups exposed to low-dose (1 x ADI) (Group 2) and high-dose (10 x ADI) (Group 3) mixtures of substances (p = 0.003), and between Group 3 and both groups exposed to high doses (10 x ADI) of the pure and commercial forms of glyphosate (Groups 4 (p = 0.014) and 5 (p = 0.007)). The micronuclei assay results were moderately correlated with the exposure period. Group 5 was the most impacted exposure group at all sampling times, with mean MN counts ranging between 28.75 & PLUSMN; 1.71 and 60.75 & PLUSMN; 1.71, followed by Group 3 (18.25 & PLUSMN; 1.50-45.75 & PLUSMN; 1.71), showing that commercial forms of glyphosate additives as well as mixtures of endocrine disruptors can enhance MN formation. All exposure groups showed statistically significant differences in micronuclei counts with an increasing time trend.
dc.language.isoeng
dc.subjectKanser Araştırmaları
dc.subjectİlaç Keşfi
dc.subjectKimya (çeşitli)
dc.subjectGenel Kimya
dc.subjectYapısal Biyoloji
dc.subjectMoleküler Biyoloji
dc.subjectKlinik Biyokimya
dc.subjectFizik Bilimleri
dc.subjectGenel Biyokimya, Genetik ve Moleküler Biyoloji
dc.subjectBiyokimya, Genetik ve Moleküler Biyoloji (çeşitli)
dc.subjectYaşlanma
dc.subjectBİYOKİMYA VE MOLEKÜLER BİYOLOJİ
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKİMYA, MULTİDİSİPLİNER
dc.subjectKimya
dc.subjectTemel Bilimler (SCI)
dc.subjectYaşam Bilimleri
dc.subjectSitogenetik
dc.subjectBiyokimya
dc.subjectAlkoloidler
dc.subjectTemel Bilimler
dc.titleDNA Damage Estimation after Chronic and Combined Exposure to Endocrine Disruptors: An In Vivo Real-Life Risk Simulation Approach
dc.typeMakale
dc.relation.journalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.contributor.departmentTechnical University of Crete , ,
dc.identifier.issue12
dc.contributor.firstauthorID4315271


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