dc.contributor.author | KARTAL, MURAT | |
dc.contributor.author | İNAL, EBRAR | |
dc.contributor.author | Nath, Ebru Özdemir | |
dc.contributor.author | KENANOĞLU, Mahmut Fırat | |
dc.contributor.author | ULUSOY, ŞEYMA | |
dc.contributor.author | İnan, Hatice Akbal | |
dc.contributor.author | Çiçek, Mahmut | |
dc.date.accessioned | 2023-10-10T10:23:58Z | |
dc.date.available | 2023-10-10T10:23:58Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | İNAL E., Nath E. Ö., KENANOĞLU M. F., ULUSOY Ş., İnan H. A., Çiçek M., KARTAL M., "Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities", Records of Natural Products, cilt.17, sa.5, 2023 | |
dc.identifier.issn | 1307-6167 | |
dc.identifier.other | av_03e236e7-a4df-4e55-8227-86e7ef3e777e | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/189233 | |
dc.identifier.uri | https://doi.org/10.25135/rnp.404.2304.2761 | |
dc.identifier.uri | https://avesis.istanbul.edu.tr/api/publication/03e236e7-a4df-4e55-8227-86e7ef3e777e/file | |
dc.description.abstract | The essential oil (EO) compositions and chemotypes of the important ethnomedicinal plant Vitex agnus-castus L. flowers, leaves, and fruits collected from Türkiye (Balıkesir and İstanbul) were identified in the present study. Different parts of the V. agnus-castus EO’s in-vitro cytotoxic effects on the MCF-7 (human breast adenocarcinoma) and A549 (human lung carcinoma) human-origin cell lines were anaylzed in the current study. The composition of hydrodistiled EOs extracted from flowers, leaves, and fruits of V. agnus-castus were analyzed by GC–FID/MS. Monoterpene hydrocarbons and oxygenated monoterpene compounds were detected as the predominant component class of the V. agnus-castus. EOs extracted from Balıkesir region were defined as the “α-pinene-1,8-cineole” chemotype, while EOs extracted from İstanbul region were defined as the “sabinene-1,8-cineole” chemotype. Sesquiterpene hydrocarbons constituted more than 20% of the compounds in the EOs extracted from the flowers. To the best of our knowledge, this study is the first to analyze the in-vitro cytotoxic effects of flowers. This study is also the first to show the in-vitro cytotoxic effects of fruit, the most commonly used part of the plant, EO on the MCF-7 cell line. Balıkesir region’s EOs were observed as more potent-especially the purple flower’s IC50 is about 4.68 µg/mL on the MCF7 cell line-than İstanbul regions, which might be attributed to the higher amount of α-pinene, caryophyllene, and limonene content. Our results indicated that the V. agnus-castus EOs, which contain α-pinene, 1,8-cineole, caryophyllene, and limonene as major components, showed relatively high cytotoxic effects compared to the control groups on the MCF7 and A549 cell lines. | |
dc.language.iso | eng | |
dc.subject | Fizik Bilimleri | |
dc.subject | Biyoinorganik Kimya | |
dc.subject | Tarım ve Çevre Bilimleri (AGE) | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Bitki ve Hayvan Bilimleri | |
dc.subject | Kimya | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | BİTKİ BİLİMLERİ | |
dc.subject | KİMYA, ORGANİK | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Eczacılık | |
dc.subject | Temel Eczacılık Bilimleri | |
dc.subject | Tarımsal Bilimler | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Farmakoloji | |
dc.subject | İlaç Keşfi | |
dc.subject | Bitki Bilimi | |
dc.subject | Organik Kimya | |
dc.subject | Ziraat | |
dc.subject | Bitki Koruma | |
dc.subject | Fitopatoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Sitogenetik | |
dc.subject | Biyokimya | |
dc.title | Chemical Composition of Different Parts of the Vitex agnus-castus L. Essential Oils and Their In-Vitro Cytotoxic Activities | |
dc.type | Makale | |
dc.relation.journal | Records of Natural Products | |
dc.contributor.department | Bezmiâlem Vakıf Üniversitesi , Eczacılık Fakültesi , Eczacılık Meslek Bilimleri Bölümü | |
dc.identifier.volume | 17 | |
dc.identifier.issue | 5 | |
dc.contributor.firstauthorID | 4556670 | |