dc.contributor.author | Karlikaya, Guvenc | |
dc.contributor.author | de Ziegler, Dominique | |
dc.contributor.author | Abali, Remzi | |
dc.contributor.author | Gultomruk, Meral | |
dc.contributor.author | Demir, Berfu | |
dc.contributor.author | Yarkiner, Zalihe | |
dc.contributor.author | Bahceci, Mustafa | |
dc.contributor.author | Boynukalin, Fazilet K. | |
dc.date.accessioned | 2023-05-29T11:37:05Z | |
dc.date.available | 2023-05-29T11:37:05Z | |
dc.identifier.citation | Boynukalin F. K., Abali R., Gultomruk M., Demir B., Yarkiner Z., Karlikaya G., Bahceci M., de Ziegler D., "Subcutaneous progesterone administration provides a similar ongoing pregnancy rate compared with intramuscular progesterone administration in hormone replacement therapy frozen embryo transfer cycles", F and S Reports, 2023 | |
dc.identifier.issn | 2666-3341 | |
dc.identifier.other | av_08a6dfaf-01c0-401a-837d-08aa3b1fc28d | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/188658 | |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85149824062&origin=inward | |
dc.identifier.uri | https://doi.org/10.1016/j.xfre.2022.11.002 | |
dc.description.abstract | Objective: To compare the ongoing pregnancy rates (OPRs) for subcutaneous progesterone (SC-P) to intramuscular progesterone (IM-P) in hormone replacement therapy used in frozen embryo transfer (FET) cycles. Design: Prospective nonrandomized cohort study. Setting: Private fertility clinic. Patient(s): The study enrolled 224 patients scheduled for hormone replacement therapy (HRT)-FET cycles with SC-P (n = 133) or IM-P (n = 91). The route of P administration was decided according to the patient's preference and accessibility to the hospital. In the first FET cycle of a freeze-all cycle using single blastocyst transfers, a woman aged ≤35 was included. Main Outcome(s): Ongoing pregnancy (OP). Result(s): The demographic, cycle, and embryologic characteristics were similar between groups. The clinical pregnancy rates (86/133[64.7%] vs. 57/91[62.6%]); miscarriage rates (21/86 [24.4%] vs. 10/57 [17.5%]), and OPR (65/133 [48.9%] vs. 47/91 [51.6%]) were comparable between the SC-P and IM-P groups. Binary logistic regression for OP as the dependent factor revealed that blastocyst morphology was found to be a significant independent prognosticator (for poor quality embryos adjusted odds ratio, 0.11; 95% confidence interval, 0.029-0.427) and progesterone route (SC-P vs. IM-P) was an insignificant prognosticator (adjusted odds ratio, 0.694; 95% confidence interval, 0.354–1.358). Conclusion(s): The OPR for SC-P administration was similar to that for IM-P in HRT-FET cycles. The effect of ET-day P levels may vary regarding the administration route. Randomized controlled trials comparing different P administration routes are needed, and large-scale prospective trials are warranted to evaluate the ET-day P levels on pregnancy outcome. | |
dc.language.iso | eng | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Kadın Hastalıkları ve Doğum | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Mikrobiyal Genetik | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Bilimler | |
dc.subject | Embriyoloji | |
dc.subject | Üreme Tıbbı | |
dc.subject | Doğum ve Jinekoloji | |
dc.subject | KADIN HASTALIKLARI & DOĞUM | |
dc.subject | ANDROLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Klinik Tıp | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | GELİŞİMSEL BİYOLOJİ | |
dc.title | Subcutaneous progesterone administration provides a similar ongoing pregnancy rate compared with intramuscular progesterone administration in hormone replacement therapy frozen embryo transfer cycles | |
dc.type | Makale | |
dc.relation.journal | F and S Reports | |
dc.contributor.department | Bahceci Health Group , , | |
dc.contributor.firstauthorID | 4258759 | |