dc.contributor.author | Başoğlu Ünal, Faika | |
dc.contributor.author | Tan, Nur | |
dc.contributor.author | Tufan, Selin | |
dc.date.accessioned | 2023-02-21T10:16:03Z | |
dc.date.available | 2023-02-21T10:16:03Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Başoğlu Ünal F., Tufan S., Tan N., "Natural phenolic compounds from Satureja L. as inhibitors of COVID19 protease (Mpro): Computational investigations ", INTERNATIONAL JOURNAL OF PLANT BASED PHARMACEUTICALS, cilt.2, sa.1, ss.111-117, 2022 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_4049bb70-e44f-461e-8412-3568f4278e4c | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/188253 | |
dc.identifier.uri | https://dergipark.org.tr/tr/pub/ijpbp/issue/64303/1051118 | |
dc.description.abstract | Coronavirus (SARS-CoV-2) causes a new type of severe acute respiratory syndrome that first appeared in Wuhan in December 2019; it is a very fast-spreading and deadly virus. Therefore, urgent discovery or development of “lead compounds” against this virus is crucial. Natural compounds have always served as a great source, especially the use of traditional medicinal plants, in modern drug discovery. This study aimed to investigate the SARS-CoV-2 protease inhibition potential of the phenolic compounds in the genus Satureja L. The affinities of the chosen natural products were understood using molecular docking simulation against the SARS-CoV-2 protease enzyme. The study proved that three different phenolic compounds namely 5,6-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one, 2- (3,4-dimethoxyphenyl)-5,6-dihydroxy-7,8-dimethoxy-4H-chromen-4-one, and 5,6-dihydroxy-2-(3-hydroxy-4- methoxyphenyl)-7,8-dimethoxy-4H-chromen-4-one obtained from Satureja L. taxa were found as promising against SARS-CoV-2 main protease. | |
dc.language.iso | eng | |
dc.subject | Farmakognozi | |
dc.subject | Farmakoloji | |
dc.subject | Farmakoloji, Toksikoloji ve Eczacılık (çeşitli) | |
dc.subject | Genel Farmakoloji, Toksikoloji ve Eczacılık | |
dc.subject | Farmakoloji (tıbbi) | |
dc.subject | İlaç Rehberleri | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Eczacılık | |
dc.subject | Meslek Bilimleri | |
dc.subject | Sağlık Bilimleri | |
dc.subject | FARMAKOLOJİ VE ECZACILIK | |
dc.subject | Farmakoloji ve Toksikoloji | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | Klinik Tıp (MED) | |
dc.title | Natural phenolic compounds from Satureja L. as inhibitors of COVID19 protease (Mpro): Computational investigations | |
dc.type | Makale | |
dc.relation.journal | INTERNATIONAL JOURNAL OF PLANT BASED PHARMACEUTICALS | |
dc.contributor.department | Lefke Avrupa Üniversitesi , Eczacılık Fakültesi , Diğer | |
dc.identifier.volume | 2 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 111 | |
dc.identifier.endpage | 117 | |
dc.contributor.firstauthorID | 3448375 | |