dc.contributor.author | Parmaksiz, Ergun | |
dc.contributor.author | ALTIPARMAK, Mehmet Rıza | |
dc.contributor.author | ATAHAN, Ersan | |
dc.contributor.author | Yalin, Serkan Feyyaz | |
dc.contributor.author | Gundogdu, Sule | |
dc.contributor.author | Mese, Meral | |
dc.contributor.author | TRABULUS, SİNAN | |
dc.contributor.author | Mutlu, Birsen | |
dc.date.accessioned | 2023-02-21T09:32:52Z | |
dc.date.available | 2023-02-21T09:32:52Z | |
dc.identifier.citation | Yalin S. F., ATAHAN E., Gundogdu S., Parmaksiz E., Mese M., TRABULUS S., Mutlu B., ALTIPARMAK M. R., "Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease?", SLEEP AND BREATHING, 2022 | |
dc.identifier.issn | 1520-9512 | |
dc.identifier.other | av_30597c24-2005-4cde-8021-d91abd04526f | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/187580 | |
dc.identifier.uri | https://doi.org/10.1007/s11325-022-02742-8 | |
dc.description.abstract | Purpose Renin-angiotensin system (RAS) hyperactivity is a common entity in both autosomal dominant polycystic kidney disease (ADPKD) and obstructive sleep apnea (OSA). We aimed to investigate the frequency of OSA in adults with ADPKD either with stages 3-4 or stages 1-2 chronic kidney disease (CKD) and evaluate the effect of RAS blockade on OSA in these patients. Methods This is a comparative, prospective, two-center clinical study. Eligible patients with ADPKD were enrolled in a polysomnography (PSG) study. Presence of OSA in patients with ADPKD was compared with individuals who underwent polisomnography study due to OSA symptoms. A subgroup analysis was performed in terms of the presence of OSA in ADPKD with eGFR values lower or higher than 60 ml/min/1.73 m(2) (stages 3-4 and stages 1-2 CKD, respectively). Results Frequency of OSA (65%) was higher than in the general population and similar between the two groups (p = 0.367). Patients with ADPKD and eGFR >= 60 ml/min/1.73 m(2) presented a similar frequency of OSA to the control group (p = 0.759). However, OSA was significantly more frequent in ADPKD with eGFR 60 ml/min/1.73 m(2)) 14/17 (82%) and 12/23 (52%), respectively (p: 0.048). Conclusion As kidney disease progresses, uremia and related factors of renal failure rather than RAS activation seem to play a more important role for the development of OSA in patients with ADPKD. | |
dc.language.iso | eng | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | KLİNİK NÖROLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.subject | Tıp | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | Nöroloji | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Solunum Bakımı | |
dc.subject | Akciğer ve Solunum Tıbbı | |
dc.subject | Nöroloji (klinik) | |
dc.subject | Yaşam Bilimleri | |
dc.title | Renin-angiotensin system activation: may it increase frequency of obstructive sleep apnea in patients with autosomal dominant polycystic kidney disease? | |
dc.type | Makale | |
dc.relation.journal | SLEEP AND BREATHING | |
dc.contributor.department | Lutfi Kirdar City Hosp , , | |
dc.contributor.firstauthorID | 4077280 | |