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dc.contributor.authorPapasavvas, Ioannis
dc.contributor.authorHerbort, Carl P.
dc.contributor.authorTugal-Tutkun, Ilknur
dc.date.accessioned2022-07-04T16:36:28Z
dc.date.available2022-07-04T16:36:28Z
dc.date.issued2022
dc.identifier.citationPapasavvas I., Tugal-Tutkun I., Herbort C. P. , "Mechanisms, Pathophysiology and Current Immunomodulatory/Immunosuppressive Therapy of Non-Infectious and/or Immune-Mediated Choroiditis", PHARMACEUTICALS, cilt.15, sa.4, 2022
dc.identifier.issn1424-8247
dc.identifier.othervv_1032021
dc.identifier.otherav_ee1a2c1f-aa9e-452b-af6c-86ad2e090361
dc.identifier.urihttp://hdl.handle.net/20.500.12627/185266
dc.identifier.urihttps://doi.org/10.3390/ph15040398
dc.description.abstractNon-infectious choroiditis comprises immune-mediated diseases resulting from diverse pathophysiological mechanisms. These conditions are sub-divided into two main groups, (1) diseases of the choriocapillaris and (2) diseases of the choroidal stroma. The purpose of this study is to expose the pathophysiology of the most common diseases of both these groups and recommend the optimal immunomodulatory/immunosuppressive therapy of each analyzed condition based on literature data and data from our own centers. Material and Methods: Narrative review. In the group of choriocapillaritis entities or primary inflammatory choriocapillaropathies (PICCPs) including multiple evanescent white dot syndrome (MEWDS), acute posterior multifocal placoid pigment epitheliopathy (APMPPE), idiopathic multifocal choroiditis (MFC) and serpiginous choroiditis (SC), as well as secondary choriocapillaritides including acute syphilitic posterior multifocal placoid chorioretinitis (ASPMPC) and tuberculosis-related SC (TB-SC), were analyzed. In the group of stromal choroidites, HLA-A29 birdshot retinochoroiditis (BRC) and Vogt-Koyanagi-Harada (VKH) disease were included. For each entity a literature search, in the PubMed database, on treatment was performed and analyzed and the therapeutic attitudes of our own centers were presented. Management of immune-mediated choroiditis implies vigorous immunosuppressive therapy given in a prompt and prolonged fashion in most of these entities.
dc.language.isoeng
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectPharmacology (medical)
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectPhysical Sciences
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectHealth Sciences
dc.subjectLife Sciences
dc.subjectSağlık Bilimleri
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.titleMechanisms, Pathophysiology and Current Immunomodulatory/Immunosuppressive Therapy of Non-Infectious and/or Immune-Mediated Choroiditis
dc.typeMakale
dc.relation.journalPHARMACEUTICALS
dc.contributor.departmentCtr Ophthalm Specialized Care COS , ,
dc.identifier.volume15
dc.identifier.issue4
dc.contributor.firstauthorID3415612


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