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dc.contributor.authorSoylemez, Esma
dc.contributor.authorKorkmaz, Serol
dc.contributor.authorTok, Olgu Enis
dc.contributor.authorAydin, Mehmet Serif
dc.contributor.authorOmurtag, Gulden Zehra
dc.contributor.authorOzcagli, Eren
dc.date.accessioned2022-07-04T11:53:31Z
dc.date.available2022-07-04T11:53:31Z
dc.identifier.citationSoylemez E., Ozcagli E., Korkmaz S., Tok O. E. , Aydin M. S. , Omurtag G. Z. , "The association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians", TOXICOLOGY AND INDUSTRIAL HEALTH, cilt.38, ss.70-79, 2022
dc.identifier.issn0748-2337
dc.identifier.othervv_1032021
dc.identifier.otherav_03f363fa-5fbd-4d24-9cd9-f5baba453050
dc.identifier.urihttp://hdl.handle.net/20.500.12627/181415
dc.identifier.urihttps://doi.org/10.1177/07482337211062680
dc.description.abstractIonizing radiation has widespread use in medicine in the diagnosis and treatment of many medical conditions. Radiology technicians are one group that is occupationally exposed to low doses of radiation. There are questions regarding whether low dose exposure to radiation could have long-term health consequences. Assessing the effect of radiation on genetic material is essential for appraising long-term health results. Hereditary variations in DNA repair genes cause differentiation in individual responses to radiation related health effects. This study aimed to determine oxidative stress and DNA damage, and their relationship to XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) polymorphisms in radiology technicians occupationally exposed to low dose radiation. Peripheral blood samples were collected from 45 radiology technicians and age-matched with 40 healthy control individuals working in office environments. Our results showed that radiology technicians had significantly greater oxidative stress and DNA damage than the control group, and women appeared more susceptible to occupational radiation exposure than men. Individuals with wild-type genotypes for XRCC1 (Arg/Arg) and XRCC3 (Thr/Thr) had less DNA damage. Lower DNA damage levels could be explained by the enhanced capacity to repair low dose radiation induced DNA damage. Further studies are needed to evaluate the role of DNA repair genes in individuals that are occupationally exposed to low dose radiation.
dc.language.isoeng
dc.subjectHealth (social science)
dc.subjectHealth, Toxicology and Mutagenesis
dc.subjectPublic Health, Environmental and Occupational Health
dc.subjectOccupational Therapy
dc.subjectEpidemiology
dc.subjectSocial Sciences & Humanities
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectSağlık Bilimleri
dc.subjectSosyal Bilimler Genel
dc.subjectSosyal Bilimler (SOC)
dc.subjectTOKSİKOLOJİ
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectKAMU, ÇEVRE VE İŞ SAĞLIĞI
dc.subjectEczacılık
dc.subjectMeslek Bilimleri
dc.subjectFarmasötik Toksikoloji
dc.subjectSosyal ve Beşeri Bilimler
dc.subjectSosyoloji
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectToxicology
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectSafety Research
dc.subjectGeneral Social Sciences
dc.titleThe association of oxidative stress and DNA damage with XRCC1 and XRCC3 polymorphisms in radiology technicians
dc.typeMakale
dc.relation.journalTOXICOLOGY AND INDUSTRIAL HEALTH
dc.contributor.departmentPendik Vet Control Inst , ,
dc.identifier.volume38
dc.identifier.startpage70
dc.identifier.endpage79
dc.contributor.firstauthorID3397940


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