Population-Specific Genetic Variation of TRAIL in Ovarian Cancer

Abstract

Objective: Genome-wide, high-throughput technologies have made major advances in understanding the molecular basis of ovarian cancer and contribution of a single genetic variant, multiple genetic variants, and the contribution of cumulative effect of a genetic variant and an environmental factor to the difference in the incidence of disease have been extensively studied. There is a progressive increase in the studies related to TRAIL mediated signaling and it has been reported that there is a highly polymorphic region in the TRAIL promoter with four SNPs located in a 111 base pair (bp) spanning sequence between nucleotides 707 and 597 upstream of the transcriptional start site.