dc.contributor.author | Saribal, Devrim | |
dc.contributor.author | Depciuch, Joanna | |
dc.contributor.author | UYULAN, ÇAĞLAR | |
dc.contributor.author | Keles, Aybike | |
dc.contributor.author | Guleken, Zozan | |
dc.date.accessioned | 2022-02-18T11:14:55Z | |
dc.date.available | 2022-02-18T11:14:55Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Guleken Z., Saribal D., UYULAN Ç., Keles A., Depciuch J., "Investigating Bio-interface Effects of Chronic ELF-MF Exposure before and after Neonatal Life on Rat Offspring Using Spectroscopy and Biochemical Assays", BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, cilt.12, sa.1, ss.795-808, 2022 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_e2208a3a-7143-4bc9-9b4c-c59d38873325 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/180748 | |
dc.identifier.uri | https://doi.org/10.33263/briac121.795808 | |
dc.description.abstract | Electromagnetic (EM) energy that generates extremely low-frequency magnetic fields (ELF-MF) impacts all living organisms' biological systems. To investigate the chronic impact of ELF-MF (50 Hz) we designed an externally applied electric field exposure to rat offspring during intrauterine and after extrauterine life. A total of 18 rat offsprings blood serum was analyzed via biochemical assays and ATR-FTIR (400 to 4000 cm(-1)) analysis. The changes in the samples' total antioxidants (TAS) and total oxidants level (TOS) were measured, and we calculated oxidative stress index (OSI) and TNF-alpha level in serum samples. To attribute diseases, chemometric models were validated using PCA-SVD analysis. Proteins, including the amide I (1631 cm(-1)), exhibit the strongest bands in the spectra depending on the secondary structure of the protein, and there was a degradation of lipids as a result of lipid peroxidation; also a significant increase in the lipid to protein ratio was concluded from the analysis (p<0.001). Finally, EMF exposure statistically significantly interferes with lipids, protein, and DNA/RNA molecules. Our findings demonstrate that chronic EMF exposure is an environmental factor affecting blood serum parameters and could impair oxidant-antioxidant function, increase lipid peroxidation and oxidative stress depending on the continuity of ELF-MF exposure. | |
dc.language.iso | eng | |
dc.subject | Process Chemistry and Technology | |
dc.subject | Physical Sciences | |
dc.subject | Temel Bilimler | |
dc.subject | General Chemistry | |
dc.subject | Chemistry (miscellaneous) | |
dc.subject | Diğer | |
dc.subject | Temel Bilimler (SCI) | |
dc.subject | Kimya | |
dc.subject | KİMYA, UYGULAMALI | |
dc.title | Investigating Bio-interface Effects of Chronic ELF-MF Exposure before and after Neonatal Life on Rat Offspring Using Spectroscopy and Biochemical Assays | |
dc.type | Makale | |
dc.relation.journal | BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | |
dc.contributor.department | Üsküdar Üniversitesi , , | |
dc.identifier.volume | 12 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 795 | |
dc.identifier.endpage | 808 | |
dc.contributor.firstauthorID | 3050330 | |