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dc.contributor.authorTETİKER, HASAN
dc.contributor.authorCİĞERCİ, İBRAHİM HAKKI
dc.contributor.authorÇELİK, ÖZGÜR İLHAN
dc.contributor.authorYILMAZ, NİGAR
dc.contributor.authorÇETİN, Esin
dc.date.accessioned2022-02-18T10:53:18Z
dc.date.available2022-02-18T10:53:18Z
dc.date.issued2017
dc.identifier.citationÇETİN E., TETİKER H., ÇELİK Ö. İ. , YILMAZ N., CİĞERCİ İ. H. , "Methotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (Viscum album L.) Extract", COMPLEMENTARY MEDICINE RESEARCH, cilt.24, sa.6, ss.364-370, 2017
dc.identifier.issn2504-2092
dc.identifier.otherav_c417e4fa-b88d-4764-8607-9a955c8502af
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/180098
dc.identifier.urihttps://doi.org/10.1159/000468984
dc.description.abstractBackground: The protective effect of mistletoe extract (Helixor((R)), HLX) against methotrexate (MTX)-induced acute oxidative stress and nephrotoxicity in rats was evaluated by histological and biochemical methods as well as the comet assay. Material and Methods: 32 female Wistar albino rats were divided into 4 groups: control group, HLX group (5 mg/kg body weight (bw), days 1-10, intraperitoneally (i.p.)), MTX group (10 mg/kg bw, days 7, 8, and 9, i.p.), and MTX + HLX group (10 mg/kg bw, days 7, 8, and 9, i.p. + 5 mg/kg bw, days 1-10, i.p.). At the end of the experiment, the glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), nitric oxide (NO), and myeloperoxidase (MPO) levels were measured, and a histopathological analysis and comet assay were carried out. Results: MTX induced renal oxidative stress and nephrotoxicity in the rats. Pretreatment with HLX significantly improved the renal GSH-Px and SOD activities in the MTX + HLX group compared to the MTX group. The decrease in the NO and MPO levels in the rat groups pretreated with HLX was not significant. The histochemical evaluation revealed that HLX provided significant improvement in the MTX-induced renal degenerative changes, including tubule distension, interstitial inflammation, perirenal inflammation, glomerular congestion, glomerular degeneration, and parenchymal hemorrhage, in the MTX + HLX group compared to the MTX-administered group. According to the comet assay, pretreatment with HLX lowered the MTX-induced DNA damage in endogenous lymphocytes, although not significantly. Conclusion: This study demonstrated that HLX administration markedly reduced the MTX-induced acute oxidative stress and nephrotoxicity in rats through its antioxidant and anti-inflammatory properties. (C) 2017 S. Karger GmbH, Freiburg
dc.language.isoeng
dc.subjectSağlık Bilimleri
dc.subjectHealth Sciences
dc.subjectComplementary and Manual Therapy
dc.subjectComplementary and Alternative Medicine
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectENTEGRE VE TAMAMLAYICI TIP
dc.titleMethotrexate-Induced Nephrotoxicity in Rats: Protective Effect of Mistletoe (Viscum album L.) Extract
dc.typeMakale
dc.relation.journalCOMPLEMENTARY MEDICINE RESEARCH
dc.contributor.departmentMuğla Sıtkı Koçman Üniversitesi , Aziz Sancar Deneysel Tıp Araştırma Enstitüsü , İmmünoloji Ana Bilim Dalı
dc.identifier.volume24
dc.identifier.issue6
dc.identifier.startpage364
dc.identifier.endpage370
dc.contributor.firstauthorID3385110


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