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Fingolimod impairs inactivated vaccine (CoronaVac)-induced antibody response to SARS-CoV-2 spike protein in persons with multiple sclerosis

dc.contributor.authorErol, Ruziye
dc.contributor.authorTüzün, Erdem
dc.contributor.authorKızılay, Tuğçe
dc.contributor.authorAkbayır, Ece
dc.contributor.authorYılmaz, Vuslat
dc.contributor.authorTürkoğlu, Recai
dc.contributor.authorBaliç, Nesrin
dc.date.accessioned2022-02-18T10:33:10Z
dc.date.available2022-02-18T10:33:10Z
dc.identifier.citationTürkoğlu R., Baliç N., Kızılay T., Erol R., Akbayır E., Yılmaz V., Tüzün E., "Fingolimod impairs inactivated vaccine (CoronaVac)-induced antibody response to SARS-CoV-2 spike protein in persons with multiple sclerosis", MULTIPLE SCLEROSIS AND RELATED DISORDERS, cilt.58, ss.103524, 2022
dc.identifier.issn2211-0348
dc.identifier.othervv_1032021
dc.identifier.otherav_a5fcb9c3-9b6b-4a00-8335-f80d40630b02
dc.identifier.urihttp://hdl.handle.net/20.500.12627/179450
dc.identifier.urihttps://doi.org/10.1016/j.msard.2022.103524
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/a5fcb9c3-9b6b-4a00-8335-f80d40630b02/file
dc.description.abstractBackground: : The impact of disease-modifying treatments on humoral response induced by inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is understudied. Methods: : We recruited 34 persons with multiple sclerosis (MS) under fingolimod treatment and 25 healthy individuals. Anti-SARS-CoV-2 spike IgG indices were measured by ELISA in sera of participants after CoronaVac vaccinations. Results: : Persons with MS displayed significantly lower antibody levels and seropositivity prevalence. Persons with MS with longer fingolimod treatment durations displayed lower anti-SARS-CoV-2 indices. Conclusion: : Our results support previous findings regarding humoral response impairing effect of fingolimod after vaccinations. Patients under fingolimod treatment may require closer monitoring for COVID-19.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectSağlık Bilimleri
dc.titleFingolimod impairs inactivated vaccine (CoronaVac)-induced antibody response to SARS-CoV-2 spike protein in persons with multiple sclerosis
dc.typeMakale
dc.relation.journalMULTIPLE SCLEROSIS AND RELATED DISORDERS
dc.contributor.department, ,
dc.identifier.volume58
dc.identifier.startpage103524
dc.identifier.endpage103524
dc.contributor.firstauthorID3060205


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