dc.contributor.author | Hemmes, Sabrine N. T. | |
dc.contributor.author | Mills, Gary H. | |
dc.contributor.author | Hollmann, Markus W. | |
dc.contributor.author | Melo, Marcos F. Vidal | |
dc.contributor.author | Putensen, Christian | |
dc.contributor.author | Schmid, Werner | |
dc.contributor.author | Severgnini, Paolo | |
dc.contributor.author | Wrigge, Hermann | |
dc.contributor.author | de Abreu, Marcelo Gama | |
dc.contributor.author | Pelosi, Paolo | |
dc.contributor.author | Schultz, Marcus J. | |
dc.contributor.author | Nijbroek, Sunny G. | |
dc.contributor.author | Hol, Liselotte | |
dc.contributor.author | Swart, Pien | |
dc.contributor.author | Neto, Ary Serpa | |
dc.contributor.author | Binnekade, Jan M. | |
dc.contributor.author | Hedenstierna, Goran | |
dc.contributor.author | Jaber, Samir | |
dc.contributor.author | Hiesmayr, Michael | |
dc.date.accessioned | 2022-02-18T10:13:44Z | |
dc.date.available | 2022-02-18T10:13:44Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Nijbroek S. G. , Hol L., Swart P., Hemmes S. N. T. , Neto A. S. , Binnekade J. M. , Hedenstierna G., Jaber S., Hiesmayr M., Hollmann M. W. , et al., "Sex difference and intra-operative tidal volume Insights from the LAS VEGAS study", EUROPEAN JOURNAL OF ANAESTHESIOLOGY, cilt.38, sa.10, ss.1034-1041, 2021 | |
dc.identifier.issn | 0265-0215 | |
dc.identifier.other | av_879f6ab6-77d0-4ce0-a541-6e50451c09e9 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/178822 | |
dc.identifier.uri | https://doi.org/10.1097/eja.0000000000001476 | |
dc.description.abstract | BACKGROUND One key element of lung-protective ventilation is the use of a low tidal volume (V-T). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients. OBJECTIVES The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference. DESIGN, PATIENTS AND SETTING This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries. MAIN OUTCOME MEASURES Women and men were compared with respect to use of LTVV, defined as V-T of 8 ml kg(-1) or less predicted bodyweight (PBW). A V-T was deemed 'default' if the set V-T was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation. RESULTS This analysis includes 9864 patients, of whom 5425 (55%) were women. A default V-T was often set, both in women and men; mode V-T was 500 ml. Median [IQR] V-T was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] ml kg(-1) PBW, P < 0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), P < 0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default V-T. CONCLUSION In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher V-T than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV. | |
dc.language.iso | eng | |
dc.subject | Anesthesiology and Pain Medicine | |
dc.subject | ANESTEZİYOLOJİ | |
dc.subject | Klinik Tıp | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Cerrahi Tıp Bilimleri | |
dc.subject | Anesteziyoloji | |
dc.subject | Health Sciences | |
dc.title | Sex difference and intra-operative tidal volume Insights from the LAS VEGAS study | |
dc.type | Makale | |
dc.relation.journal | EUROPEAN JOURNAL OF ANAESTHESIOLOGY | |
dc.contributor.department | University of Amsterdam , , | |
dc.identifier.volume | 38 | |
dc.identifier.issue | 10 | |
dc.identifier.startpage | 1034 | |
dc.identifier.endpage | 1041 | |
dc.contributor.firstauthorID | 3388422 | |