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Intracoronary pharmacotherapy in the management of coronary microvascular dysfunction

dc.contributor.authorNethala, Navin
dc.contributor.authorKunadian, Vijayalakshmi
dc.contributor.authorZorkun, Cafer
dc.contributor.authorWilliams, Scott P.
dc.contributor.authorBiller, Leah H.
dc.contributor.authorGibson, William J.
dc.contributor.authorLew, Michelle E.
dc.contributor.authorPalmer, Alexandra M.
dc.contributor.authorOgando, Katherine J.
dc.contributor.authorGibson, C. Michael
dc.contributor.authorBuros, Jacqueline L.
dc.contributor.authorMarble, Susan J.
dc.date.accessioned2022-02-18T10:08:40Z
dc.date.available2022-02-18T10:08:40Z
dc.date.issued2008
dc.identifier.citationKunadian V., Zorkun C., Williams S. P. , Biller L. H. , Palmer A. M. , Ogando K. J. , Lew M. E. , Nethala N., Gibson W. J. , Marble S. J. , et al., "Intracoronary pharmacotherapy in the management of coronary microvascular dysfunction", JOURNAL OF THROMBOSIS AND THROMBOLYSIS, cilt.26, sa.3, ss.234-242, 2008
dc.identifier.issn0929-5305
dc.identifier.otherav_7ef51f71-52e7-4990-9bf0-89e3730eaf6f
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/178637
dc.identifier.urihttps://doi.org/10.1007/s11239-008-0276-0
dc.description.abstractAlthough percutaneous coronary intervention restores optimal epicardial blood flow in most cases, abnormal myocardial perfusion may still persist. This might be as a result of macro and microembolization, neutrophil plugging, vasoconstriction, myocyte contracture, local intracellular and interstitial edema, intramural haemorrhage, and endothelial blistering. Local delivery of intracoronary pharmacotherapy via the coronary arteries may increase local drug concentration several fold, and may improve drug efficacy. Several pharmacological agents such as adenosine, calcium channel blockers, alpha blockers, beta(2) receptor activators, vasodilators, antithrombotics, and antiplatelet agents have been used to treat coronary microvascular dysfunction. This article reviews the results of trials of intracoronary pharmacotherapy to date.
dc.language.isoeng
dc.subjectİç Hastalıkları
dc.subjectCARDIAC ve CARDIOVASCULAR SİSTEMLER
dc.subjectKlinik Tıp
dc.subjectKlinik Tıp (MED)
dc.subjectHEMATOLOJİ
dc.subjectPERİFERAL VASKÜLER HASTALIĞI
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectDahili Tıp Bilimleri
dc.subjectHematoloji
dc.subjectKardiyoloji
dc.subjectCardiology and Cardiovascular Medicine
dc.subjectHematology
dc.subjectHealth Sciences
dc.titleIntracoronary pharmacotherapy in the management of coronary microvascular dysfunction
dc.typeMakale
dc.relation.journalJOURNAL OF THROMBOSIS AND THROMBOLYSIS
dc.contributor.departmentHarvard University , ,
dc.identifier.volume26
dc.identifier.issue3
dc.identifier.startpage234
dc.identifier.endpage242
dc.contributor.firstauthorID3376248


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