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Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia

dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorFanous, Ayman H.
dc.contributor.authorFrank, Josef
dc.contributor.authorKelly, Brian
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMortensen, Preben B.
dc.contributor.authorMowry, Bryan J.
dc.contributor.authorPato, Carlos N.
dc.contributor.authorPeriyasamy, Sathish
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRujescu, Dan
dc.contributor.authorSimonsen, Carmen
dc.contributor.authorSt Clair, David
dc.contributor.authorTooney, Paul
dc.contributor.authorWu, Jing Qin
dc.contributor.authorAndreassen, Ole A.
dc.contributor.authorKowalec, Kaarina
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorMurray, Robin M.
dc.contributor.authorOwen, Michael J.
dc.contributor.authorMacCabe, James H.
dc.contributor.authorO'Donovan, Michael C.
dc.contributor.authorWalters, James T. R.
dc.contributor.authorPardinas, Antonio F.
dc.contributor.authorSmart, Sophie E.
dc.contributor.authorWillcocks, Isabella R.
dc.contributor.authorHolmans, Peter A.
dc.contributor.authorDennison, Charlotte A.
dc.contributor.authorLynham, Amy J.
dc.contributor.authorLegge, Sophie E.
dc.contributor.authorBigdeli, Tim B.
dc.contributor.authorCairns, Murray J.
dc.contributor.authorCorvin, Aiden
dc.date.accessioned2022-02-18T09:38:33Z
dc.date.available2022-02-18T09:38:33Z
dc.identifier.citationPardinas A. F. , Smart S. E. , Willcocks I. R. , Holmans P. A. , Dennison C. A. , Lynham A. J. , Legge S. E. , Baune B. T. , Bigdeli T. B. , Cairns M. J. , et al., "Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia", JAMA PSYCHIATRY, 2022
dc.identifier.issn2168-622X
dc.identifier.othervv_1032021
dc.identifier.otherav_4fbcaead-46ba-4267-afde-d931d044acf4
dc.identifier.urihttp://hdl.handle.net/20.500.12627/177647
dc.identifier.urihttps://doi.org/10.1001/jamapsychiatry.2021.3799
dc.description.abstractIMPORTANCE About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectHealth Sciences
dc.subjectPsikiyatri
dc.subjectPsychiatric Mental Health
dc.subjectPsychiatry and Mental Health
dc.subjectSağlık Bilimleri
dc.titleInteraction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia
dc.typeMakale
dc.relation.journalJAMA PSYCHIATRY
dc.contributor.departmentFamily Institute, Cardiff , ,
dc.contributor.firstauthorID3134496


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