dc.contributor.author | Orfanos, CE | |
dc.contributor.author | Daniel, P | |
dc.contributor.author | Eberle, J | |
dc.contributor.author | Geilen, CC | |
dc.contributor.author | Raisova, M | |
dc.contributor.author | BEKTAŞ, Muhammet | |
dc.contributor.author | Wieder, T | |
dc.date.accessioned | 2022-02-18T09:33:20Z | |
dc.date.available | 2022-02-18T09:33:20Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Raisova M., BEKTAŞ M., Wieder T., Daniel P., Eberle J., Orfanos C., Geilen C., "Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release", FEBS LETTERS, cilt.473, sa.1, ss.27-32, 2000 | |
dc.identifier.issn | 1873-3468 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_45a83158-a109-45bc-8d2c-82cdeb4e0acf | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/177435 | |
dc.identifier.uri | https://doi.org/10.1016/s0014-5793(00)01491-5 | |
dc.description.abstract | Intracellular CD95/Fas-signaling pathways have not been investigated in melanoma yet, Two different CD95 receptor-induced apoptotic pathways are presently known in other cell types: (i) direct activation of caspase-8 and (ii) induction of ceramide-mediated mitochondrial activation, both leading to subsequent caspase-3 activation. In the present study, five of II melanoma cell populations were shown to release cytochrome c from mitochondria, which activates caspase-3 and finally results in DNA fragmentation upon treatment with the agonistic monoclonal antibody CH-11. In contrast, this apoptotic pathway was not activated in the remaining six melanoma cell populations, interestingly, the susceptibility of melanoma cells to CD95L/FasL-triggered cell death was clearly correlated with N-acetylsphingosine-mediated apoptosis, Our results are in line with a defect upstream of mitochondrial cytochrome c release in resistant cells. (C) 2000 Federation of European Biochemical Societies. | |
dc.language.iso | eng | |
dc.subject | Cancer Research | |
dc.subject | Molecular Biology | |
dc.subject | Drug Discovery | |
dc.subject | Aging | |
dc.subject | Health Sciences | |
dc.subject | Biochemistry | |
dc.subject | Biophysics | |
dc.subject | Structural Biology | |
dc.subject | Biochemistry (medical) | |
dc.subject | Life Sciences | |
dc.subject | General Biochemistry, Genetics and Molecular Biology | |
dc.subject | BİYOKİMYA VE MOLEKÜLER BİYOLOJİ | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Yaşam Bilimleri (LIFE) | |
dc.subject | BİYOFİZİK | |
dc.subject | Biyoloji ve Biyokimya | |
dc.subject | HÜCRE BİYOLOJİSİ | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Temel Tıp Bilimleri | |
dc.subject | Biyofizik | |
dc.subject | Biyokimya | |
dc.subject | Histoloji-Embriyoloji | |
dc.subject | Yaşam Bilimleri | |
dc.subject | Moleküler Biyoloji ve Genetik | |
dc.subject | Sitogenetik | |
dc.subject | Temel Bilimler | |
dc.subject | Biochemistry, Genetics and Molecular Biology (miscellaneous) | |
dc.subject | Clinical Biochemistry | |
dc.subject | Cell Biology | |
dc.title | Resistance to CD95/Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release | |
dc.type | Makale | |
dc.relation.journal | FEBS LETTERS | |
dc.contributor.department | , , | |
dc.identifier.volume | 473 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 27 | |
dc.identifier.endpage | 32 | |
dc.contributor.firstauthorID | 3371818 | |