The Frequency of XRCC1 DNA Repair Gene A399G Polymorphism In The Western Anatolia

Abstract

The aim of this study is to determine the frequency of polymorphism in codon 399 region of XRCC1 gene in the healthy Western Anatolian population. XRCC1-399 polymorphism is studied in the control group of 100 people living in Izmir, Turkey, who don't have a cancer story, using the method of PCR-RFLP (Msp I Restriction Endonuclease enzyme). The followings are found out as a result of the analyses: the frequency of the ones having A/A genotype is 44.0 %, the frequency of the ones having A/G genotype is 41.0 % and the frequency of the ones having GIG genotype is 15.0 %. Allel frequencies are found to be 64.5 % for A nucleotide and 35.5 % fOr G nucleotide. When the results obtained are compared with various populations, the homozygosity rate for Allel A and Allel G is determined to be at a similar value as the Indian, American, English, Korean and Chinese populations.