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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium

dc.contributor.authorBreen, Gerome
dc.contributor.authorBoomsma, Dorret I.
dc.contributor.authorLevinson, Douglas F.
dc.contributor.authorBaune, Bernhard T.
dc.contributor.authorNelson, Elliot N.
dc.contributor.authorPeyrot, Wouter J.
dc.contributor.authorVan der Auwera, Sandra
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorDolan, Conor V.
dc.contributor.authorMadden, Pamela A. F.
dc.contributor.authorSullivan, Patrick F.
dc.contributor.authorStrohmaier, Jana
dc.contributor.authorRipke, Stephan
dc.contributor.authorRietschel, Marcella
dc.contributor.authorNivard, Michel G.
dc.contributor.authorMullins, Niamh
dc.contributor.authorMontgomery, Grant W.
dc.contributor.authorHenders, Anjali K.
dc.contributor.authorHeat, Andrew C.
dc.contributor.authorFisher, Helen L.
dc.contributor.authorDunn, Erin C.
dc.contributor.authorByrne, Enda M.
dc.contributor.authorAir, Tracy A.
dc.contributor.authorDepressive, Major
dc.contributor.authorGrabe, Hans J.
dc.contributor.authorWray, Naomi R.
dc.contributor.authorPenninx, Brenda W. J. H.
dc.contributor.authorMartin, Nick G.
dc.contributor.authorLewis, Cathryn M.
dc.date.accessioned2022-02-18T09:10:21Z
dc.date.available2022-02-18T09:10:21Z
dc.date.issued2018
dc.identifier.citationPeyrot W. J. , Van der Auwera S., Milaneschi Y., Dolan C. V. , Madden P. A. F. , Sullivan P. F. , Strohmaier J., Ripke S., Rietschel M., Nivard M. G. , et al., "Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium", BIOLOGICAL PSYCHIATRY, cilt.84, sa.2, ss.138-147, 2018
dc.identifier.issn0006-3223
dc.identifier.otherav_1f6a8521-5c8c-48ef-a6ed-b4e5f847caf7
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/176642
dc.identifier.urihttps://doi.org/10.1016/j.biopsych.2017.09.009
dc.description.abstractBACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS 3 CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample.
dc.language.isoeng
dc.subjectPsychiatric Mental Health
dc.subjectPsychiatry and Mental Health
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectSağlık Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectDevelopmental Neuroscience
dc.subjectCellular and Molecular Neuroscience
dc.subjectCognitive Neuroscience
dc.subjectGeneral Neuroscience
dc.subjectNeuroscience (miscellaneous)
dc.subjectSensory Systems
dc.subjectHuman-Computer Interaction
dc.subjectKlinik Tıp (MED)
dc.subjectPsikiyatri
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectSinirbilim ve Davranış
dc.subjectNEUROSCIENCES
dc.titleDoes Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
dc.typeMakale
dc.relation.journalBIOLOGICAL PSYCHIATRY
dc.contributor.departmentVrije Universiteit Amsterdam , ,
dc.identifier.volume84
dc.identifier.issue2
dc.identifier.startpage138
dc.identifier.endpage147
dc.contributor.firstauthorID3386323


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