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Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva

dc.contributor.authorCuong, NM
dc.contributor.authorFong, HHS
dc.contributor.authorXuan, LT
dc.contributor.authorSoejarto, DD
dc.contributor.authorPezzuto, JM
dc.contributor.authorZhang, HJ
dc.contributor.authorTamez, PA
dc.contributor.authorAydogmus, Z
dc.contributor.authorTan, GT
dc.contributor.authorSaikawa, Y
dc.contributor.authorHashimoto, K
dc.contributor.authorNakata, M
dc.contributor.authorVan Hung, N
dc.date.accessioned2022-02-18T09:05:18Z
dc.date.available2022-02-18T09:05:18Z
dc.date.issued2002
dc.identifier.citationZhang H., Tamez P., Aydogmus Z., Tan G., Saikawa Y., Hashimoto K., Nakata M., Van Hung N., Xuan L., Cuong N., et al., "Antimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva", PLANTA MEDICA, cilt.68, sa.12, ss.1088-1091, 2002
dc.identifier.issn0032-0943
dc.identifier.otherav_1797726c-c409-41ec-90c2-7447be58f917
dc.identifier.othervv_1032021
dc.identifier.urihttp://hdl.handle.net/20.500.12627/176487
dc.identifier.urihttps://doi.org/10.1055/s-2002-36350
dc.description.abstractBioassay-directed fractionation of an extract prepared from the dried leaves and stem barks of Ficus fistulosa Reinw. ex Blume (Moraceae) led to the isolation of verrucarin L acetate (1), together with 3alpha-hydroxyisohop-22(29)-en-24-oic acid, 3beta-gluco-sitosterol, 3,4-dihydro-6,7-dimethoxyisocarbostyril, 3,4,5-trimethoxybenzyl alcohol, alpha-methyl-3,4,5-trimethoxybenzyl alcohol, indole-3-carboxaldehyde, palmanine, and aurantiamide acetate. Roridin E (2) was identified in a subfraction from the dried leaves and stems of Rhaphidophora decursiva Schott (Araceae). Verrucarin L acetate and roridin E were characterized as macrocyclic trichothecene sesquiterpenoids and found to inhibit the growth of Plasmodium falciparum with IC50 values below I ng/ml.
dc.language.isoeng
dc.subjectKlinik Tıp (MED)
dc.subjectFARMAKOLOJİ VE ECZACILIK
dc.subjectFarmakoloji ve Toksikoloji
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectEczacılık
dc.subjectTemel Eczacılık Bilimleri
dc.subjectTarımsal Bilimler
dc.subjectZiraat
dc.subjectENTEGRE VE TAMAMLAYICI TIP
dc.subjectFitopatoloji
dc.subjectYaşam Bilimleri
dc.subjectBiyokimya
dc.subjectTemel Bilimler
dc.subjectPlant Science
dc.subjectPharmacology
dc.subjectGeneral Pharmacology, Toxicology and Pharmaceutics
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectChemistry (miscellaneous)
dc.subjectGeneral Chemistry
dc.subjectComplementary and Manual Therapy
dc.subjectPharmacology (medical)
dc.subjectComplementary and Alternative Medicine
dc.subjectPharmacy
dc.subjectDrug Guides
dc.subjectSmall Animals
dc.subjectPhysical Sciences
dc.subjectLife Sciences
dc.subjectHealth Sciences
dc.subjectBitki Koruma
dc.subjectKlinik Tıp
dc.subjectTemel Bilimler (SCI)
dc.subjectKimya
dc.subjectKİMYA, TIP
dc.subjectTarım ve Çevre Bilimleri (AGE)
dc.subjectBitki ve Hayvan Bilimleri
dc.subjectBİTKİ BİLİMLERİ
dc.titleAntimalarial agents from plants. III. Trichothecenes from Ficus fistulosa and Rhaphidophora decursiva
dc.typeMakale
dc.relation.journalPLANTA MEDICA
dc.contributor.department, ,
dc.identifier.volume68
dc.identifier.issue12
dc.identifier.startpage1088
dc.identifier.endpage1091
dc.contributor.firstauthorID3372196


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