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dc.contributor.authorTardu, Mehmet
dc.contributor.authorDunn, Cory D.
dc.contributor.authorKavakli, I. Halil
dc.contributor.authorBaytek, Gulkiz
dc.contributor.authorGaripler, Gorkem
dc.contributor.authorAkdogan, Emel
dc.date.accessioned2021-12-10T11:51:33Z
dc.date.available2021-12-10T11:51:33Z
dc.date.issued2016
dc.identifier.citationAkdogan E., Tardu M., Garipler G., Baytek G., Kavakli I. H. , Dunn C. D. , "Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA", PLOS ONE, cilt.11, sa.1, 2016
dc.identifier.issn1932-6203
dc.identifier.othervv_1032021
dc.identifier.otherav_98ea4141-7e83-4f63-9a0a-2866a9c84d8f
dc.identifier.urihttp://hdl.handle.net/20.500.12627/172764
dc.identifier.urihttps://avesis.istanbul.edu.tr/api/publication/98ea4141-7e83-4f63-9a0a-2866a9c84d8f/file
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0146511
dc.description.abstractDamage to the mitochondrial genome (mtDNA) can lead to diseases for which there are no clearly effective treatments. Since mitochondrial function and biogenesis are controlled by the nutrient environment of the cell, it is possible that perturbation of conserved, nutrient-sensing pathways may successfully treat mitochondrial disease. We found that restricting glucose or otherwise reducing the activity of the protein kinase A (PKA) pathway can lead to improved proliferation of Saccharomyces cerevisiae cells lacking mtDNA and that the transcriptional response to mtDNA loss is reduced in cells with diminished PKA activity. We have excluded many pathways and proteins from being individually responsible for the benefits provided to cells lacking mtDNA by PKA inhibition, and we found that robust import of mitochondrial polytopic membrane proteins may be required in order for cells without mtDNA to receive the full benefits of PKA reduction. Finally, we have discovered that the transcription of genes involved in arginine biosynthesis and aromatic amino acid catabolism is altered after mtDNA damage. Our results highlight the potential importance of nutrient detection and availability on the outcome of mitochondrial dysfunction.
dc.language.isoeng
dc.subjectDoğa Bilimleri Genel
dc.subjectÇOK DİSİPLİNLİ BİLİMLER
dc.subjectMultidisciplinary
dc.subjectTemel Bilimler
dc.subjectTemel Bilimler (SCI)
dc.titleReduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA
dc.typeMakale
dc.relation.journalPLOS ONE
dc.contributor.departmentKoç Üniversitesi , ,
dc.identifier.volume11
dc.identifier.issue1
dc.contributor.firstauthorID2692910


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