dc.contributor.author | Bajars, Marcis | |
dc.contributor.author | Barlesi, Fabrice | |
dc.contributor.author | Yang, James C-H | |
dc.contributor.author | Ruisi, Mary | |
dc.contributor.author | Manitz, Juliane | |
dc.contributor.author | Park, Keunchil | |
dc.contributor.author | ÖZGÜROĞLU, Mustafa | |
dc.contributor.author | Vansteenkiste, Johan | |
dc.contributor.author | Spigel, David | |
dc.date.accessioned | 2021-12-10T11:45:04Z | |
dc.date.available | 2021-12-10T11:45:04Z | |
dc.identifier.citation | Park K., ÖZGÜROĞLU M., Vansteenkiste J., Spigel D., Yang J. C. , Bajars M., Ruisi M., Manitz J., Barlesi F., "Impact of subsequent immune checkpoint inhibitor treatment on overall survival with avelumab vs docetaxel in platinum-treated advanced NSCLC: Post hoc analyses from the phase 3 JAVELIN Lung 200 trial", LUNG CANCER, cilt.154, ss.92-98, 2021 | |
dc.identifier.issn | 0169-5002 | |
dc.identifier.other | vv_1032021 | |
dc.identifier.other | av_92603e4d-6d28-4227-9c45-fcfcd918e442 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12627/172546 | |
dc.identifier.uri | https://doi.org/10.1016/j.lungcan.2021.01.026 | |
dc.description.abstract | Objectives: The JAVELIN Lung 200 phase 3 trial did not meet its primary endpoint of improving overall survival (OS) with avelumab vs docetaxel in patients with platinum-treated PD-L1+ NSCLC. We report post hoc analyses assessing the effects of subsequent immune checkpoint inhibitor (ICI) treatment on OS. Material and methods: Patients with stage IIIB/IV NSCLC progressed following platinum-doublet therapy were randomized to receive avelumab or docetaxel. OS was analyzed in the PD-L1+ population (?1% of tumor cells) and full analysis set (PD-L1+ or PD-L1-). Effects of subsequent ICI (after permanent discontinuation of study treatment) on OS were analyzed using a preplanned naive sensitivity analysis and post hoc inverse probability of censoring weighting (IPCW) analysis. Subgroups with or without subsequent ICI treatment were analyzed using descriptive statistics. Results: In the avelumab and docetaxel arms, a subsequent ICI was received by 16/396 (4.0 %) and 104/396 (26.3 %) after a median of 10.5 months (range, 3.9?20.4) and 5.7 months (range, 0.1?24.4), respectively. Some subgroups showed trends for higher subsequent ICI treatment, including patients with non-squamous NSCLC (avelumab arm, 4.3 % vs docetaxel arm, 32.1 %) or with a baseline ECOG performance status of 0 (6.3 % vs 31.3 %); those enrolled in the early recruitment wave (11.6 % vs 54.3 %), or enrolled in the US/Western Europe (2.8 % vs 45.5 %) or Asia (11.0 % vs 35.4 %); and non-white patients (10.1 % vs 35.0 %). The hazard ratio for OS with avelumab vs docetaxel was lower in the IPCW analysis than in the naive sensitivity analysis (PD-L1+ population: 0.80 [95 % CI, 0.62-1.04] vs 0.86 [95 % CI, 0.68-1.09], respectively). Conclusion: In the JAVELIN Lung 200 trial, avelumab showed clinical activity as second-line treatment for patients with advanced NSCLC. Post hoc analyses suggest that the primary OS analysis may have been confounded by subsequent ICI use in the docetaxel arm. ClinicalTrials.gov identifier: NCT02395172. | |
dc.language.iso | eng | |
dc.subject | Göğüs Hastalıkları ve Allerji | |
dc.subject | İç Hastalıkları | |
dc.subject | Onkoloji | |
dc.subject | Oncology | |
dc.subject | Respiratory Care | |
dc.subject | Pulmonary and Respiratory Medicine | |
dc.subject | Health Sciences | |
dc.subject | Tıp | |
dc.subject | Sağlık Bilimleri | |
dc.subject | Dahili Tıp Bilimleri | |
dc.subject | SOLUNUM SİSTEMİ | |
dc.subject | Klinik Tıp (MED) | |
dc.subject | Klinik Tıp | |
dc.subject | ONKOLOJİ | |
dc.title | Impact of subsequent immune checkpoint inhibitor treatment on overall survival with avelumab vs docetaxel in platinum-treated advanced NSCLC: Post hoc analyses from the phase 3 JAVELIN Lung 200 trial | |
dc.type | Makale | |
dc.relation.journal | LUNG CANCER | |
dc.contributor.department | Sungkyunkwan University (SKKU) , , | |
dc.identifier.volume | 154 | |
dc.identifier.startpage | 92 | |
dc.identifier.endpage | 98 | |
dc.contributor.firstauthorID | 2633292 | |