Acute infectious exacerbations in chronic obstructive lung disease and effects of azithromycine, sultamycilline, ciprofloxacin and cefaclor monohydrate Kronik obstruktif akciger hastaligi olgularinda akut infeksiyon doneminde patojen ajanin saptanmasi ve azitromisin, sultamisilin, siprofloksasin ve sefaklor monohidratin etkinligi

Abstract

Background and Design. Lower respiratory tract infections cause great morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to find out the causative organism and the effects of azithromycine, ampicillin sulbactam (sultamycilline), ciprofloxacin and cefaclor monohydrate therapy in COPD. One hundred and sixteen patients with COPD in acute exacerbation were randomized into four groups for antibiotic treatment following lung function test and sputum. Results. The most common strains were H. influenzae (30.8%), S. pneumoniae (12.0%) and M. catarrhalis (7.7%). Conclusion. H. influenza is the most common causative organism in acute infectious attacks of COPD. Azithromycine, ampicilline sulbactam (Sultamycilline), ciprofloxacin and cefaclor monohydrate are of value in the treatment of acute infectious attacks of COPD.