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dc.contributor.authorDONMA, Orkide
dc.contributor.authorMadazli, Riza
dc.contributor.authorYilmaz, Nevin
dc.contributor.authorSÖNMEZ, Hüseyin Avni
dc.contributor.authorAcikgoz, Abdullah
dc.contributor.authorTÜTEN, Abdullah
dc.contributor.authorGungor, Zeynep
dc.contributor.authorEkmekci, Hakan
dc.contributor.authorEkmekci, Ozlem Balci
dc.contributor.authorKUCUR, Mine
dc.date.accessioned2021-03-15T15:10:41Z
dc.date.available2021-03-15T15:10:41Z
dc.date.issued2021
dc.identifier.citationTÜTEN A., Gungor Z., Ekmekci H., Ekmekci O. B. , KUCUR M., Yilmaz N., DONMA O., SÖNMEZ H. A. , Acikgoz A., Madazli R., "Relationship between LPA SNPs and inflammatory burden in patients with preeclampsia to address future cardiovascular risk", JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, cilt.34, sa.6, ss.898-906, 2021
dc.identifier.issn1476-7058
dc.identifier.othervv_1032021
dc.identifier.otherav_25130ce3-faca-452c-be9d-b9b2f6ed6e16
dc.identifier.urihttp://hdl.handle.net/20.500.12627/167820
dc.identifier.urihttps://doi.org/10.1080/14767058.2019.1622667
dc.description.abstractObjective: The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors. Background: Studies have shown that women specific risk factors for cardiovascular disease (CVD) have taken an attention recently. It might be possible to identify women who have the highest risk in developing CVD in their further lives. It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. Further, LPA risk genotypes are not considered in cardiovascular risk prediction. Methods: We have included 200 pregnant Turkish women into the study. We stratified the preeclamptic (PE) group: early (EOP) (28.7 +/- 3.0 weeks) and late onset (LOP) (36.0 +/- 1.4 weeks). 14 LPA SNPs were evaluated in the study. Rs9355296 and rs3798220 were found as independent risk factors for preeclampsia by logistic regression analysis. A positive correlation was found between rs9355296 and the diagnostic criteria of preeclampsia. Further rs9355296 G/* carriers have higher vascular inflammation rather than AA carriers. Conclusions: The findings reveal that LPA genetic variability with high inflammatory response might be an indication of future cardiovascular events.
dc.language.isoeng
dc.subjectHealth Sciences
dc.subjectCerrahi Tıp Bilimleri
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectSağlık Bilimleri
dc.subjectTıp
dc.subjectKlinik Tıp (MED)
dc.subjectKlinik Tıp
dc.subjectKADIN HASTALIKLARI & DOĞUM
dc.subjectObstetrics and Gynecology
dc.titleRelationship between LPA SNPs and inflammatory burden in patients with preeclampsia to address future cardiovascular risk
dc.typeMakale
dc.relation.journalJOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
dc.contributor.departmentİstanbul Teknik Üniversitesi , Cerrahpaşa Tıp Fakültesi , Cerrahi Tıp Bilimleri Bölümü
dc.identifier.volume34
dc.identifier.issue6
dc.identifier.startpage898
dc.identifier.endpage906
dc.contributor.firstauthorID2529981


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