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dc.contributor.authorAkgul, S. U.
dc.contributor.authorOguz, F. S.
dc.contributor.authorCaliskan, Y.
dc.contributor.authorKekik, C.
dc.contributor.authorCagatay, Penbe
dc.contributor.authorTurkmen, A.
dc.contributor.authorNane, I.
dc.contributor.authorAydın, Feyyaz Fatih
dc.contributor.authorTemurhan, Sonay
dc.date.accessioned2021-03-08T08:41:43Z
dc.date.available2021-03-08T08:41:43Z
dc.date.issued2013
dc.identifier.citationAkgul S. U. , Oguz F. S. , Caliskan Y., Kekik C., Cagatay P., Turkmen A., Nane I., Aydın F. F. , Temurhan S., "The effect of anti-human leukocyte antigen, anti-major histocompatibility complex class 1 chain-related antigen a, and anti-glutathione transferase-T1 antibodies on the long-term survival of renal allograft.", Transplantation proceedings, cilt.45, sa.3, ss.890-4, 2013
dc.identifier.issn0041-1345
dc.identifier.othervv_1032021
dc.identifier.otherav_09345869-a667-46cf-aa7b-0b9c78c288b9
dc.identifier.urihttp://hdl.handle.net/20.500.12627/167585
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2013.02.097
dc.description.abstractBackground. One of the most important mechanisms of allograft rejection is the production ofdonor-specific antibodies (DSA). Anti-major histocompatibility complex class-I chain-relatedantigen A (MICA) and anti-glutathione S transferase-T1 (GSTT1) antibodies cause graft dysfunctionand reduce graft survival. The aim of this study was to examine the effects of anti-humanleukocyte antigen class I–II, anti-MICA, and anti-GSTT1 antibodies in development of antibodymediatedrejection.Methods. Among the 32 renal transplant patients included in this study 65% experiencedantibody-mediated rejection (AMR; chronic activeAMR[CAMR], n17; acuteAMR[AAMR],n 4) and 35%, ACR. The anti-HLA class I–II and anti-MICA antibodies were determined byusing LUMINEX, anti-GSTT1 antibodies by enzyme-linked immunosorbent assay. GSTT1genotyping of patients and donors was performed by polymerase chain reaction.Results. Antibody was detected in 19 of 21 patients undergoing antibody-mediated rejection(90%). We detected anti-GSTT1 in 4, anti-MICA in 8, anti-HLA class I in 5, and anti-HLA classII in 9 patients withCAMR(P.007). If the patients were divided into 2 groups according to beingC4d and C4d both anti-HLA class I and class II antibodies were found significantly morefrequently among the C4d group (P .019, P .024). No difference was determined betweenAMR and ACR groups in terms of anti-GSTT1 and anti-MICA antibodies.Conclusions. In this study, we observed the role of anti-HLA class II antibodies in thedevelopment of CAMR and in long-term allograft survival. It is observed that anti-MICA andanti-GSTT1 antibodies showed no effect on rejection mechanisms.
dc.language.isoeng
dc.subjectKlinik Tıp
dc.subjectTıp
dc.subjectSağlık Bilimleri
dc.subjectCerrahi Tıp Bilimleri
dc.subjectYaşam Bilimleri
dc.subjectTemel Bilimler
dc.subjectKlinik Tıp (MED)
dc.subjectTRANSPLANTASYON
dc.subjectCERRAHİ
dc.subjectYaşam Bilimleri (LIFE)
dc.subjectİmmünoloji
dc.titleThe effect of anti-human leukocyte antigen, anti-major histocompatibility complex class 1 chain-related antigen a, and anti-glutathione transferase-T1 antibodies on the long-term survival of renal allograft.
dc.typeMakale
dc.relation.journalTransplantation proceedings
dc.contributor.departmentİstanbul Üniversitesi , ,
dc.identifier.volume45
dc.identifier.issue3
dc.identifier.startpage890
dc.identifier.endpage4
dc.contributor.firstauthorID2520571


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